5-Carboxylcytosine and cytosine protonation distinctly alter the stability and dehybridization dynamics of the DNA duplex
Applications associated with nucleobase protonation events are grounded in their
fundamental impact on DNA thermodynamics, structure, and hybridization dynamics. Of the …
fundamental impact on DNA thermodynamics, structure, and hybridization dynamics. Of the …
[HTML][HTML] Urinary measurement of epigenetic DNA modifications and 8-oxodG as possible noninvasive markers of colon cancer evolution
A Skalska-Bugala, A Siomek-Gorecka… - International Journal of …, 2022 - mdpi.com
The active DNA demethylation mechanism involves 5-methylcytosine (5-mCyt) enzymatic
oxidation with the subsequent formation of 5-hydroxymethylcytosine (5-hmCyt), which can …
oxidation with the subsequent formation of 5-hydroxymethylcytosine (5-hmCyt), which can …
Substrate specificities of DNA glycosylases in vitro and in vivo
AV Endutkin, DO Zharkov - 2020 - books.rsc.org
DNA glycosylases are enzymes that initiate the base excision repair (BER) pathway. 1 BER,
a highly conserved process, protects the genome from chemically diverse lesions …
a highly conserved process, protects the genome from chemically diverse lesions …
[HTML][HTML] Effects of Tet-mediated Oxidation Products of 5-Methylcytosine on DNA Transcription in vitro and in Mammalian Cells
methylcytosine (5-mC) is a well-characterized epigenetic regulator in mammals. Recent
studies showed that Ten-eleven translocation (Tet) proteins can catalyze the stepwise …
studies showed that Ten-eleven translocation (Tet) proteins can catalyze the stepwise …
Mechanism of the glycosidic bond cleavage of mismatched thymine in human thymine DNA glycosylase revealed by classical molecular dynamics and quantum …
N Kanaan, R Crehuet, P Imhof - The Journal of Physical Chemistry …, 2015 - ACS Publications
Base excision of mismatched or damaged nucleotides catalyzed by glycosylase enzymes is
the first step of the base excision repair system, a machinery preserving the integrity of DNA …
the first step of the base excision repair system, a machinery preserving the integrity of DNA …
DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å
Y Liu, YO Olanrewaju, X Zhang, X Cheng - Biochemistry, 2013 - ACS Publications
The Zfp57 gene encodes a KRAB (Krüppel-associated box) domain-containing C2H2 zinc
finger transcription factor that is expressed in early development. Zfp57 protein recognizes …
finger transcription factor that is expressed in early development. Zfp57 protein recognizes …
[HTML][HTML] An enzyme-mediated bioorthogonal labeling method for genome-wide mapping of 5-hydroxymethyluracil
CJ Ma, L Li, WX Shao, JH Ding, XL Cai, ZR Lun… - Chemical …, 2021 - pubs.rsc.org
DNA 5-hydroxymethyluracil (5hmU) is a thymine modification existing in the genomes of
various organisms. The post-replicative formation of 5hmU occurs via hydroxylation of …
various organisms. The post-replicative formation of 5hmU occurs via hydroxylation of …
[HTML][HTML] A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation
Thymine DNA glycosylase (TDG) functions in base excision repair, a DNA repair pathway
that acts in a lesion-specific manner to correct individual damaged or altered bases. TDG …
that acts in a lesion-specific manner to correct individual damaged or altered bases. TDG …
Effect of a U: G mispair on the water around DNA
DNA repair proteins are able to discriminate DNA lesions among an abundance of intact
DNA with high selectivity. To investigate detectable characteristics of one specific lesion, we …
DNA with high selectivity. To investigate detectable characteristics of one specific lesion, we …
[HTML][HTML] Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process: Structural …
L Wang, K Song, J Yu, LT Da - Acta Biochimica et Biophysica …, 2022 - ncbi.nlm.nih.gov
DNA glycosylase, as one member of DNA repair machineries, plays an essential role in
correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond …
correcting mismatched/damaged DNA nucleotides by cleaving the N-glycosidic bond …