Glycans are the most abundant biopolymers on earth and are constituents of glycoproteins,
glycolipids, and proteoglycans with multiple biological functions. The availability of different …

Few classes of natural products rival the structural audacity of oligosaccharides. Their
complexity, however, has stood as an immense roadblock to translational research, as …

Nucleotide sugars play an elementary role in nature as building blocks of glycans,
polysaccharides, and glycoconjugates used in the pharmaceutical, cosmetics, and food …

The multienzyme cascade has received growing attention to obtain structurally defined
glycans in vitro. However, due to poor enzyme stability and low compatibility between …

Abstract Guanosine 5'‐diphospho‐β‐l‐fucose (GDP‐Fuc) is an important and expensive
nucleotide sugar only available in low quantities. We established two processes for the gram …

The addition of the O-linked N-acetylglucosamine (O-GlcNAc) is a significant modification for
active molecules, such as proteins, carbohydrates, and natural products. However, the …

Deoxythymidine diphospho-l-rhamnose (dTDP-l-rhamnose) is used by prokaryotic
rhamnosyltransferases as the glycosyl donor for the synthesis of rhamnose-containing …

Glycans, including oligosaccharides and glycoconjugates, play an integral role in
modulating the biological functions of macromolecules. Many physiological and pathological …

Complex poly-and oligosaccharides on the surface of bacteria provide a unique fingerprint
to different strains of pathogenic and symbiotic microbes that could be exploited for …

The non-sulfated chondroitin backbone (CH) is the synthetic precursor of chondroitin sulfate,
a linear polysaccharide with dramatic biological functions. Owing to the intrinsic …