As our understanding of the cell interior has grown, we have come to appreciate that most
cellular operations are localized, that is, they occur at discrete and identifiable locations or …

By superlocalizing the positions of millions of single molecules over many camera frames, a
class of super-resolution fluorescence microscopy methods known as single-molecule …

Anomalous-diffusion, the departure of the spreading dynamics of diffusing particles from the
traditional law of Brownian-motion, is a signature feature of a large number of complex soft …

A eukaryotic cell is a microscopic world within which efficient material transport is essential.
Yet, how a cell manages to deliver cellular cargos efficiently in a crowded environment …

Extracellular vesicles (EVs) are cell-secreted particles with broad potential to treat tissue
injuries by delivering cargo to program target cells. However, improving the yield of …

While fundamentally important, the intracellular diffusion of small (≲ 1 kDa) solutes has been
difficult to elucidate due to challenges in both labeling and measurement. Here we quantify …

Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs) and
leads to progressive vision loss. The first pathological signs can be seen at the optic nerve …

During skeletal development, bone growth and mineralization require transport of
substantial amounts of calcium, while maintaining very low concentration. How an organism …

The interior of a living cell is an active, fluctuating, and crowded environment, yet it maintains
a high level of coherent organization. This dichotomy is readily apparent in the intracellular …

Diffusion of nanoparticles in the cytoplasm of live cells has frequently been reported to
exhibit an anomalous and even heterogeneous character, ie particles seem to switch gears …