Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus–positive oropharyngeal squamous cell carcinoma
Background Human papillomavirus (HPV)–associated oropharyngeal cancer is a disease
clinically and biologically distinct from smoking‐related head and neck squamous cell …
clinically and biologically distinct from smoking‐related head and neck squamous cell …
[HTML][HTML] A clinical and molecular portrait of non-metastatic anal squamous cell carcinoma
S Iseas, M Golubicki, J Robbio, G Ruiz, F Guerra… - Translational …, 2021 - Elsevier
Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy associated with
high-risk Human papillomavirus (HPV) infection. Despite improved outcomes in non …
high-risk Human papillomavirus (HPV) infection. Despite improved outcomes in non …
[HTML][HTML] Molecular and immunophenotypic characterization of anal squamous cell carcinoma reveals distinct clinicopathologic groups associated with HPV and TP53 …
X Zhu, S Jamshed, J Zou, A Azar, X Meng, V Bathini… - Modern Pathology, 2021 - Elsevier
Squamous cell carcinoma (SqCC) is the most common malignancy of the anal canal, where
it is strongly associated with HPV infection. Characteristic genomic alterations have been …
it is strongly associated with HPV infection. Characteristic genomic alterations have been …
Differential spatial gene and protein expression associated with recurrence following chemoradiation for localized anal squamous cell cancer
S Hernandez, P Das, EB Holliday, L Shen, W Lu… - Cancers, 2023 - mdpi.com
Simple Summary While anti-PD1 antibodies have demonstrated efficacy in some patients
with metastatic anal cancer, these agents have no proven benefit for those with localized …
with metastatic anal cancer, these agents have no proven benefit for those with localized …
The role of immunotherapy in the treatment of anal cancer and future strategies
AA Jacome, VK Morris, C Eng - Current treatment options in oncology, 2022 - Springer
Opinion statement Despite being markedly sensitive to chemoradiotherapy, patients with
locally advanced (T3-4 and/or node-positive) squamous cell carcinoma of the anal canal …
locally advanced (T3-4 and/or node-positive) squamous cell carcinoma of the anal canal …
The management and prevention of anal squamous cell carcinoma
C Eng, C Messick, R Glynne-Jones - American Society of Clinical …, 2019 - ascopubs.org
Our aim is to discuss the current established management of care and associated
prevention strategies of anal squamous cell carcinoma (SCCA). In general, the development …
prevention strategies of anal squamous cell carcinoma (SCCA). In general, the development …
Genomic landscape of primary and recurrent anal squamous cell carcinomas in relation to HPV integration, copy-number variation, and DNA damage response genes
J Aldersley, DR Lorenz, KW Mouw, AD D'Andrea… - Molecular Cancer …, 2021 - AACR
The incidence of anal squamous cell carcinoma (ASCC) has been increasing, particularly in
populations with HIV. Human papillomavirus (HPV) is the causal factor in 85% to 90% of …
populations with HIV. Human papillomavirus (HPV) is the causal factor in 85% to 90% of …
[HTML][HTML] Molecular characterization of squamous cell carcinoma of the anal canal
Background Squamous cell carcinoma of the anal canal (SCCA) is an uncommon
malignancy with limited therapeutic options. Nivolumab and pembrolizumab show promising …
malignancy with limited therapeutic options. Nivolumab and pembrolizumab show promising …
[HTML][HTML] Exome sequencing reveals aberrant signalling pathways as hallmark of treatment-naive anal squamous cell carcinoma
W Cacheux, V Dangles-Marie, E Rouleau… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Anal squamous cell carcinomas (ASCC) are rare tumours in humans. The etiological role of
HPV infection is now well established but little is known about the molecular landscape and …
HPV infection is now well established but little is known about the molecular landscape and …
Integrated genomic and transcriptomic analysis reveals the activation of PI3K signaling pathway in HPV-independent cervical cancers
Y Wang, M He, T He, X Ouyang, X Shen, W Shi… - British Journal of …, 2024 - nature.com
Background HPV-independent cervical cancers (HPV-ind CCs) are uncommon with worse
prognosis and poorly understood. This study investigated the molecular characteristics of …
prognosis and poorly understood. This study investigated the molecular characteristics of …