Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus–positive oropharyngeal squamous cell carcinoma

S Haft, S Ren, G Xu, A Mark, K Fisch, TW Guo, Z Khan… - Cancer, 2019 - Wiley Online Library
Background Human papillomavirus (HPV)–associated oropharyngeal cancer is a disease
clinically and biologically distinct from smoking‐related head and neck squamous cell …

[HTML][HTML] A clinical and molecular portrait of non-metastatic anal squamous cell carcinoma

S Iseas, M Golubicki, J Robbio, G Ruiz, F Guerra… - Translational …, 2021 - Elsevier
Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy associated with
high-risk Human papillomavirus (HPV) infection. Despite improved outcomes in non …

[HTML][HTML] Molecular and immunophenotypic characterization of anal squamous cell carcinoma reveals distinct clinicopathologic groups associated with HPV and TP53 …

X Zhu, S Jamshed, J Zou, A Azar, X Meng, V Bathini… - Modern Pathology, 2021 - Elsevier
Squamous cell carcinoma (SqCC) is the most common malignancy of the anal canal, where
it is strongly associated with HPV infection. Characteristic genomic alterations have been …

Differential spatial gene and protein expression associated with recurrence following chemoradiation for localized anal squamous cell cancer

S Hernandez, P Das, EB Holliday, L Shen, W Lu… - Cancers, 2023 - mdpi.com
Simple Summary While anti-PD1 antibodies have demonstrated efficacy in some patients
with metastatic anal cancer, these agents have no proven benefit for those with localized …

The role of immunotherapy in the treatment of anal cancer and future strategies

AA Jacome, VK Morris, C Eng - Current treatment options in oncology, 2022 - Springer
Opinion statement Despite being markedly sensitive to chemoradiotherapy, patients with
locally advanced (T3-4 and/or node-positive) squamous cell carcinoma of the anal canal …

The management and prevention of anal squamous cell carcinoma

C Eng, C Messick, R Glynne-Jones - American Society of Clinical …, 2019 - ascopubs.org
Our aim is to discuss the current established management of care and associated
prevention strategies of anal squamous cell carcinoma (SCCA). In general, the development …

Genomic landscape of primary and recurrent anal squamous cell carcinomas in relation to HPV integration, copy-number variation, and DNA damage response genes

J Aldersley, DR Lorenz, KW Mouw, AD D'Andrea… - Molecular Cancer …, 2021 - AACR
The incidence of anal squamous cell carcinoma (ASCC) has been increasing, particularly in
populations with HIV. Human papillomavirus (HPV) is the causal factor in 85% to 90% of …

[HTML][HTML] Molecular characterization of squamous cell carcinoma of the anal canal

SA Armstrong, R Malley, H Wang, HJ Lenz… - Journal of …, 2021 - ncbi.nlm.nih.gov
Background Squamous cell carcinoma of the anal canal (SCCA) is an uncommon
malignancy with limited therapeutic options. Nivolumab and pembrolizumab show promising …

[HTML][HTML] Exome sequencing reveals aberrant signalling pathways as hallmark of treatment-naive anal squamous cell carcinoma

W Cacheux, V Dangles-Marie, E Rouleau… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Anal squamous cell carcinomas (ASCC) are rare tumours in humans. The etiological role of
HPV infection is now well established but little is known about the molecular landscape and …

Integrated genomic and transcriptomic analysis reveals the activation of PI3K signaling pathway in HPV-independent cervical cancers

Y Wang, M He, T He, X Ouyang, X Shen, W Shi… - British Journal of …, 2024 - nature.com
Background HPV-independent cervical cancers (HPV-ind CCs) are uncommon with worse
prognosis and poorly understood. This study investigated the molecular characteristics of …