Introduction Anal cancer, a rare malignancy accounting for 2.5–3.0% of gastrointestinal
cancers, primarily manifests as squamous cell carcinoma associated with HPV. Recent …

Squamous cell carcinoma of the anal canal (SCCA) is an HPV-related malignancy with
rising incidence in the past few decades in the US, characterized by high rates of complete …

Purpose We examined the concordance of genetic mutations between pretreatment tumor
tissue and posttreatment circulating tumor DNA (ctDNA) in patients with metastatic …

Anal squamous cell carcinoma (ASCC) is a rare neoplasm. Chemoradiotherapy is the
standard of care, with no therapeutic advances achieved over the past three decades. Thus …

The incidence and mortality of squamous cell carcinoma of the anus (SCCA) is on the rise,
which highlights the unmet need for advances in treatment options. The landscape of …

Background and Objectives There is limited evidence to guide the management of patients
with oligometastatic anal squamous cell carcinoma (SCC). We aimed to address this …

Introduction Anal dysplasia and anal cancer are major health problems. This study seeks to
determine if inhibition of mTOR and/or PI3K pathways is effective at anal cancer prevention …

Rare reports of anal carcinoma (AC) describe histologic resemblance to cutaneous
cylindroma, but mutations in the tumor suppressor CYLD, the gene responsible for familial …

Circulating tumor DNA (ctDNA) as a blood-based biomarker for mutation detection is an
exciting, highly sensitive approach in the clinical management of oncology patients. In …

Objectives Metastatic squamous cell carcinoma anal cancer (SCCA) is rare. Prospective
data recommends front-line platinum doublet combinations and second-line anti …