Diabetic nephropathy (DN) is a progressive microvascular complication arising from
diabetes. Within the kidney, the glomeruli, tubules, vessels and interstitium are disrupted …

Diabetes is a common metabolic disease whose hyperglycemic state can induce diverse
complications and even threaten human health and life security. Currently, the treatment of …

Oxidative insult, inflammation, apoptosis and autophagy play a pivotal role in the etiology of
diabetic nephropathy, a global health concern. Ferulic acid, a phytochemical, is reported to …

Podocytes constitute the outer layer of the renal glomerular filtration barrier. Their energy
requirements strongly depend on efficient oxidative respiration, which is tightly connected …

Imbalance of M1/M2 macrophages phenotype activation is a key point in diabetic
nephropathy (DN). Macrophages mainly exhibit M1 phenotype, which contributes to the …

Quercetin can reverse high glucose-induced inhibition of neural cell proliferation, and
therefore may have a neuroprotective effect in diabetic peripheral neuropathy. It is difficult to …

As a high energy consumption organ, kidney relies on a large number of mitochondria to
ensure normal physiological activities. Under specific stimulation, mitophagy and …

Autophagy is a major cellular clearance mechanism that maintains cellular survival and
homeostasis. Autophagy has a crucial role in the progression of diabetes and kidney …

Aim Acute hyperglycemia is closely related to kidney injury. Oxidative stress activation and
notable mitochondria damages were found under acute hyperglycemia treatment in our …

The cell biological phenomenon of autophagy has attracted increasing attention in recent
years, partly as a consequence of the discovery of key components of its cellular machinery …