[HTML][HTML] Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer's and Parkinson's disease

N Reich, C Hölscher - Frontiers in Neuroendocrinology, 2024 - Elsevier
Cholecystokinin (CCK) is a neuropeptide modulating digestion, glucose levels,
neurotransmitters and memory. Recent studies suggest that CCK exhibits neuroprotective …

Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats

D Tse, L Privitera, AC Norton… - Proceedings of the …, 2023 - National Acad Sciences
Memory formation is typically divided into phases associated with encoding, storage,
consolidation, and retrieval. The neural determinants of these phases are thought to differ …

Targeting G protein-coupled receptors in the treatment of Parkinson's disease

J Jones-Tabah - Journal of Molecular Biology, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized in part
by the deterioration of dopaminergic neurons which leads to motor impairment. Although …

Role of dopamine agonists in Parkinson's disease therapy

D Woitalla, C Buhmann, R Hilker-Roggendorf… - Journal of Neural …, 2023 - Springer
Dopamine agonists are an important component of Parkinson's therapy. When weighing up
the various therapy options, therapy with levodopa has recently been increasingly preferred …

Dopamine and dopamine-related ligands can bind not only to dopamine receptors

J Myslivecek - Life, 2022 - mdpi.com
The dopaminergic system is one of the most important neurotransmitter systems in the
central nervous system (CNS). It acts mainly by activation of the D1-like receptor family at the …

The circadian neurobiology of reward

I Olejniczak, K Begemann, I Wilhelm… - Acta …, 2023 - Wiley Online Library
Circadian clocks are important regulators of physiology and behavior. In the brain, circadian
clocks have been described in many centers of the central reward system. They affect …

A Cre-dependent reporter mouse for quantitative real-time imaging of protein kinase A activity dynamics

EI Tilden, A Maduskar, A Oldenborg, BL Sabatini… - Scientific reports, 2024 - nature.com
Intracellular signaling dynamics play a crucial role in cell function. Protein kinase A (PKA) is
a key signaling molecule that has diverse functions, from regulating metabolism and brain …

The neuropharmacological properties of α‐pyrrolidinobutiothiophenone, a new synthetic cathinone, in rodents; role of the dopaminergic system

OH Kim, KO Jeon, G Kim, CG Jang… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose α‐Pyrrolidinobutiothiophenone (α‐PBT) is a chemical
derivative of cathinone, a structural analogue of amphetamine. Until now, there have been a …

G Protein-Dependent Activation of the PKA-Erk1/2 Pathway by the Striatal Dopamine D1/D3 Receptor Heteromer Involves Beta-Arrestin and the Tyrosine …

F Bono, Z Tomasoni, V Mutti, G Sbrini, R Kumar… - Biomolecules, 2023 - mdpi.com
The heteromer composed of dopamine D1 and D3 receptors (D1R–D3R) has been defined
as a structure able to trigger Erk1/2 and Akt signaling in a G protein-independent, beta …

[HTML][HTML] The electrical stimulation of the central nucleus of the amygdala in combination with dopamine receptor antagonist reduces the acquisition phase of morphine …

Z Jokar, S Khatamsaz, H Alaei… - Research in …, 2023 - journals.lww.com
Background and purpose: The central nucleus of the amygdala (CeA) is one of the nuclei
involved in the reward system. The aim of the current study was to investigate the electrical …