Despite a substantial appreciation for the critical role of macrophages in cardiometabolic
diseases, understanding of human macrophage biology has been hampered by the lack of …

Current protocols support red cell production that mimics embryonic and fetal hematopoiesis
and cell yield sufficient for diagnostic RBC reagents. Ongoing challenges to generate RBCs …

It is increasingly recognized that specialized subsets of endothelial cells carry out unique
functions in specific organs and regions of the vascular tree. Perhaps the most striking …

The production of in vitro–derived platelets has great potential for transfusion medicine.
Here, we build on our experience in the forward programming (FoP) of human pluripotent …

Hematopoiesis, the process of blood formation, is controlled by a complex developmental
program that involves intrinsic and extrinsic regulators. Blood formation is critical to normal …

Red blood cell (RBC) transfusion is one of the most common medical treatments, with more
than 10 million units transfused per year in the United States alone. Alloimmunization to …

Several protocols exist for generating megakaryocytes (MKs) and platelets from human
induced pluripotent stem cells (hiPSCs) with limited efficiency. We observed previously that …

Derivation of functional and mature red blood cells (RBCs) with adult globin expression from
renewable source such as induced pluripotent stem cells (iPSCs) is of importance from the …

The developmental origin of blood-forming hematopoietic stem cells (HSCs) is a
longstanding question. Here, our non-invasive genetic lineage tracing in mouse embryos …

Doxycycline (DOX), an antibacterial drug, has been widely used in the inducible gene
expression system. However, its effect was largely ignored when studying functions of the …