Neutrophils as emerging therapeutic targets

T Németh, M Sperandio, A Mócsai - Nature reviews Drug discovery, 2020 - nature.com
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

[HTML][HTML] The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF

S Ghalehbandi, J Yuzugulen, MZI Pranjol… - European Journal of …, 2023 - Elsevier
Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …

[HTML][HTML] Neutrophil-derived cytokines: facts beyond expression

C Tecchio, A Micheletti, MA Cassatella - Frontiers in immunology, 2014 - frontiersin.org
Polymorphonuclear neutrophils, besides their involvement in primary defense against
infections–mainly through phagocytosis, generation of toxic molecules, release of enzymes …

Combined diagnostic efficacy of neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and mean platelet volume (MPV) as biomarkers of systemic …

M Stojkovic Lalosevic, A Pavlovic Markovic… - Disease …, 2019 - Wiley Online Library
Background. Systemic inflammation in colorectal cancer (CRC) may be reflected by
neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and mean platelet …

Social networking of human neutrophils within the immune system

P Scapini, MA Cassatella - Blood, The Journal of the American …, 2014 - ashpublications.org
It is now widely recognized that neutrophils are highly versatile and sophisticated cells that
display de novo synthetic capacity and may greatly extend their lifespan. In addition …

Neutrophil-derived chemokines on the road to immunity

C Tecchio, MA Cassatella - Seminars in immunology, 2016 - Elsevier
During recent years, it has become clear that polymorphonuclear neutrophils are remarkably
versatile cells, whose functions go far beyond phagocytosis and killing. In fact, besides …

[HTML][HTML] Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil extracellular traps

SB Kwak, SJ Kim, J Kim, YL Kang, CW Ko… - … & Molecular Medicine, 2022 - nature.com
Surgery is unanimously regarded as the primary strategy to cure solid tumors in the early
stages but is not always used in advanced cases. However, tumor surgery must be carefully …

The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding

F Schatz, O Guzeloglu-Kayisli, S Arlier… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND Human pregnancy requires robust hemostasis to prevent hemorrhage
during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification …

[HTML][HTML] Neutrophil extracellular traps, angiogenesis and cancer

R Poto, L Cristinziano, L Modestino, A de Paulis… - Biomedicines, 2022 - mdpi.com
Human neutrophils, the most abundant circulating leukocytes, are fundamental components
of the host response against different pathogens. Until a few years ago, neutrophils received …

Anti-tumor immune potentiation targets-engineered nanobiotechnologies: design principles and applications

R Jiao, X Lin, Q Zhang, Y Zhang, W Qin, Q Yang… - Progress in Materials …, 2023 - Elsevier
Combined therapeutic strategies hold promises in augmenting antigen release to enhance
anti-tumor immunity, which have garnered attention in numerous scholarly reviews. Beyond …