An overview of natural plant products in the treatment of hepatocellular carcinoma

D Rawat, S Shrivastava, RA Naik… - Anti-Cancer Agents …, 2018 - ingentaconnect.com
Background: Liver cancer is the fifth most commonly diagnosed cancer and the second
leading cause of cancer-related deaths worldwide. Among the liver cancers, hepatocellular …

[HTML][HTML] Small molecule inhibitors for hepatocellular carcinoma: advances and challenges

MA Kamal, YM Mandour, MK Abd El-Aziz, U Stein… - Molecules, 2022 - mdpi.com
Highlights: Multi tyrosine kinase inhibitors licensed for HCC treatment. Multi kinase inhibitors
not licensed for HCC treatment. Inhibitors of Growth Factor Receptors. Small molecules …

[HTML][HTML] Identification of m6A-and ferroptosis-related lncRNA signature for predicting immune efficacy in hepatocellular carcinoma

H Xie, M Shi, Y Liu, C Cheng, L Song, Z Ding… - Frontiers in …, 2022 - frontiersin.org
Background N6-methyladenosine (m6A) methylation and ferroptosis assist long noncoding
RNAs (lncRNAs) in promoting immune escape in hepatocellular carcinoma (HCC) …

[HTML][HTML] Emerging treatment modalities for systemic therapy in hepatocellular carcinoma

X Qing, W Xu, J Zong, X Du, H Peng, Y Zhang - Biomarker Research, 2021 - Springer
Hepatocellular carcinoma (HCC) has long been a major global clinical problem as one of
the most common malignant tumours with a high rate of recurrence and mortality. Although …

T-box transcription factor 19 promotes hepatocellular carcinoma metastasis through upregulating EGFR and RAC1

X Ji, X Chen, B Zhang, M Xie, T Zhang, X Luo, D Liu… - Oncogene, 2022 - nature.com
The effect of targeted therapy for metastatic hepatocellular carcinoma (HCC) is still
unsatisfactory. Exploring the underlying mechanism of HCC metastasis is favorable to …

Emerging tyrosine kinase inhibitors for the treatment of hepatocellular carcinoma

L de Rosamel, JF Blanc - Expert opinion on emerging drugs, 2017 - Taylor & Francis
Introduction: Hepatocellular carcinoma (HCC) is the fifth most diagnosed cancer in the world
and the third leading cause of death. Unfortunately, when diagnosed two thirds of patients …

Research progresses of targeted therapy and immunotherapy for hepatocellular carcinoma

T Wang, Q Zhang, N Wang, Z Liu… - Current Medicinal …, 2021 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide,
with nearly one million new cases and deaths every year. Owing to the complex …

Role of systemic therapy and future directions for hepatocellular carcinoma

J Eatrides, E Wang, N Kothari, R Kim - Cancer Control, 2017 - journals.sagepub.com
Hepatocellular carcinoma (HCC) is an aggressive tumor that often arises in the setting of
liver cirrhosis. Although early-stage disease is often amenable for surgical resection …

Vorinostat-loaded titanium oxide nanoparticles (anatase) induce G2/M cell cycle arrest in breast cancer cells via PALB2 upregulation

S Abdel-Ghany, S Raslan, H Tombuloglu… - 3 Biotech, 2020 - Springer
Breast cancer is a group of diseases in which cells divide out of controlled, typically resulting
in a mass. Erlotinib is targeted cancer drug which functions as an inhibitor of the epidermal …

2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop

S Zheng, J Ni, Y Li, M Lu, Y Yao, H Guo, M Jiao… - Pharmacological …, 2021 - Elsevier
Erlotinib, an EGFR tyrosine kinase inhibitor has been introduced into cancer chemotherapy.
However, the therapeutic effects of erlotinib in hepatocellular carcinoma (HCC) remain …