Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant
metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a …

Metastatic prostate carcinoma overexpresses prostate-specific membrane antigen (PSMA),
making this antigen a suitable target for radioligand therapy of the disease. Here we report …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Radioresistance is a major challenge in prostate cancer (CaP) radiotherapy (RT). In this
study, we investigated the role and association of epithelial–mesenchymal transition (EMT) …

Abstract The PI3K/Akt/mTOR pathway has a central role in cancer metastasis and
radiotherapy. To develop effective therapeutics to improve radiosensitivity, understanding …

Radiotherapy is a curative treatment option in prostate cancer. Nevertheless, patients with
high-risk prostate cancer are prone to relapse. Identification of the predictive biomarkers and …

Background Inosine 5′-monophosphate dehydrogenase type II (IMPDH2) was originally
identified as an oncogene in several human cancers. However, the clinical significance and …

Abstract The phosphatidylinositol-3-kinase/Akt and the mammalian target of rapamycin
(PI3K/Akt/mTOR) pathway is one of the most frequently activated signaling pathways in …

Background During tumor formation and expansion, increasing glucose metabolism is
necessary for unrestricted growth of tumor cells. Expression of key glycolytic enzyme alpha …