BACKGROUND: Patients undergoing major abdominal surgery are at risk of both bleeding
and thrombotic complications and usually receive heparin thromboprophylaxis. PATIENTS …

Vascular intimal carcinomatosis refers to a characteristic tumor proliferation on vascular
intima that replaces normal endothelium. This pathological event of unknown cause is quite …

The activation of coagulation and fibrinolysis is frequently found among cancer patients.
Such tumors are considered to be associated with a higher risk of invasion, metastases, and …

It has long been recognized that the vascular endothelium is a major target of bacterial
endotoxin and of a variety of microorganisms, and that damage to endothelial cells (ECs) is …

Hypercoagulability can be defined as a condition of procoagulant imbalance due to
heightened enzymatic activation of coagulation zymogens, but with no laboratory evidence …

Proteases and their respective inhibitors are found in almost every biological system where
proteolysis occurs. Examples of such systems include the processing of proteins during …

Abstract The Fenretinide (4‐HPR) Breast Cancer Study is a randomized multicenter clinical
trial designed to evaluate the effectiveness of the synthetic retinoid 4‐HPR, at a dose of 200 …

Background: Plasminogen activators (PA) may be released by the gut and eliminated by the
liver. Patients with liver disorders or malignancy often have abnormal plasma levels of PAs …

Background Surgery is the first treatment of a pigmented skin lesion when a melanoma is
suspected. This excision is most of the time realized by the dermatologist as well as the …

Abstract Plasminogen activator inhibitor-1 (PAI-1) is a single chain glycoprotein of
approximately 50,000 Daltons which is synthesized by endothelial cells and hepatocytes. It …