Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human
exposome. However, DNT data from animal studies are available for only a small …

A problem facing the product development community is developing simultaneous solutions
of response variables (to several properties) that depends on a number of independent …

To transfer toxicological findings from model systems, eg animals, to humans, standardized
safety factors are applied to account for intra-species and inter-species variabilities. An …

Current animal-free methods to assess teratogenicity of drugs under development still
deliver high numbers of false negatives. To improve the sensitivity of human teratogenicity …

Background Studying human germ cell development and male infertility is heavily relied on
mouse models. In vitro differentiation of human pluripotent stem cells into spermatogonial …

Impact ionization of high-velocity cosmic dust particles has been used as a basic principle
for dust detectors in space for many decades. It has provided optimum means to gain insight …

This manuscript provides a review focused on embryonic stem cell-based models and their
place within the landscape of alternative developmental toxicity assays. Against the …

Animal studies for embryotoxicity evaluation of potential therapeutics and environmental
factors are complex, costly, and time-consuming. Often, studies are not of human relevance …

Human-relevant tests to predict developmental toxicity are urgently needed. A currently
intensively studied approach makes use of differentiating human stem cells to measure …

Most functional genomic studies are conducted in steady-state conditions, therefore
providing a description of molecular processes at a particular moment of cell differentiation …