Melatonin is remarkably functionally diverse with actions as a free radical scavenger and
antioxidant, circadian rhythm regulator, anti‐inflammatory and immunoregulating molecule …

Sepsis-associated cerebral dysfunction is complex pathophysiology, generated from primary
infections that are developed elsewhere in the body. The neonates, elderly population and …

Much progress has been achieved to elucidate the function of lactoferrin (LTF), an iron-
binding glycoprotein, in the milieu of immune functionality. This review represents a unique …

Classically, mitochondria have largely been believed to influence the development of illness
by modulating cell metabolism and determining the rate of production of high-energy …

Background Sepsis-induced organ failure is the major cause of death in critical care units,
and is characterized by a massive dysregulated inflammatory response and oxidative stress …

Lactoferrin, an iron-binding glycoprotein, is a cell-secreted mediator that bridges innate and
adaptive immune function in mammals. It is a pleiotropic molecule that directly assists in the …

Background Sepsis is a life-threatening condition accompanied by organ dysfunction
subsequent to a dysregulated host response to infection. Up to 60% of patients with sepsis …

Cardiac dysfunction is common in patients with severe sepsis and septic shock. Current
understanding of the underlying mechanisms responsible is rapidly evolving and future …

Alzheimer's disease (AD) is a primary cause of dementia in the middle-aged and elderly
worldwide. Animal models for AD are widely used to study the disease mechanisms as well …

Background. Cardiac dysfunction is present in> 40% of sepsis patients and is associated
with mortality rates of up to 70%. Recent evidence suggests that glycolytic metabolism plays …