BACKGROUND AND PURPOSE Cannabis extracts and several cannabinoids have been
shown to exert broad anti‐inflammatory activities in experimental models of inflammatory …

Background/Aims: The activation of cannabinoid receptor 2 (CB2) has the beneficial effect of
reducing neuroinflammatory response in the treatment of Alzheimer's disease (AD) and is …

Background Anandamide (AEA) is an endogenous lipid mediator that exerts several effects
in the brain as well as in peripheral tissues. These effects are mediated mainly by two types …

Abstract Cannabidiol (CBD) and∆ 9-tetrahydrocannabinol (THC) have well documented
immunomodulatory effects in vitro, but not following oral administration in humans. Here we …

Microglia, brain cells of nonneural origin, orchestrate the inflammatory response to diverse
insults, including hypoxia/ischemia or maternal/fetal infection in the perinatal brain …

The Cannabis sativa plant has been exploited for medicinal, agricultural and spiritual
purposes in diverse cultures over thousands of years. Cannabis has been used …

Alterations in the endogenous cannabinoid system have been described in almost every
category of disease. These changes can alternatively be protective or maladaptive, such as …

The endocannabinoid system (ECS), a conserved physiological system emerged as a novel
pharmacological target for its significant role and potential therapeutic benefits ranging from …

Cisplatin is an important chemotherapeutic agent; however, its nephrotoxicity limits its
clinical use. Enhanced inflammatory response and oxidative/nitrosative stress seem to play …

The opioid system consists of three receptors, mu, delta, and kappa, which are activated by
endogenous opioid peptides (enkephalins, endorphins, and dynorphins). The endogenous …