Melanoma, melanin, and melanogenesis: The Yin and Yang relationship

RM Slominski, T Sarna, PM Płonka, C Raman… - Frontiers in …, 2022 - frontiersin.org
Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet
radiation and other environmental stressors. It is produced by the enzymatic transformation …

Melanin of fungi: From classification to application

R Liu, X Meng, C Mo, X Wei, A Ma - World Journal of Microbiology and …, 2022 - Springer
Melanin is a secondary metabolite composed of complex heterogeneous polymers. Fungal
melanin is considered to be a sustainable and biodegradable natural pigment and has a …

Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role

FA Zucca, A Capucciati, C Bellei, M Sarna, T Sarna… - IUBMB …, 2023 - Wiley Online Library
Neuromelanins are compounds accumulating in neurons of human and animal brain during
aging, with neurons of substantia nigra and locus coeruleus having the highest levels of …

[HTML][HTML] Noninvasive detection of the endogenous free radical melanin in human skin melanomas using electron paramagnetic resonance (EPR)

L Mignion, CM Desmet, E Harkemanne… - Free Radical Biology …, 2022 - Elsevier
We explored the capability of low-frequency Electron Paramagnetic Resonance (EPR) to
noninvasively detect melanin (a stable semiquinone free radical) in the human skin. As …

Eumelanin from the Black Soldier fly as sustainable Biomaterial: Characterisation and functional benefits in tissue-Engineered Composite scaffolds

U D'Amora, A Soriente, A Ronca, S Scialla, M Perrella… - Biomedicines, 2022 - mdpi.com
An optimized extraction protocol for eumelanins from black soldier flies (BSF-Eumel) allows
an in-depth study of natural eumelanin pigments, which are a valuable tool for the design …

The metabolism of melanin synthesis—From melanocytes to melanoma

M Snyman, RE Walsdorf, SN Wix… - Pigment Cell & …, 2024 - Wiley Online Library
Melanin synthesis involves the successful coordination of metabolic pathways across
multiple intracellular compartments including the melanosome, mitochondria, ER/Golgi, and …

Phenolic polymers as model melanins

HA Galeb, J Eichhorn, S Harley… - Macromolecular …, 2023 - Wiley Online Library
Melanins are a class of conjugated biopolymers with varying compositions and functions,
which have a variety of potential medical and technical applications. Here, this work …

Dihydroxynaphthalene-based allomelanins: A source of inspiration for innovative technological materials

V Lino, P Manini - ACS omega, 2022 - ACS Publications
Melanins are a wide class of natural pigments biosynthesized by different kinds of living
organisms throughout all of the life domains, from bacteria to fungi, plants, and mammals …

Towards characterization of skin melanoma in the clinic by electron paramagnetic resonance (EPR) spectroscopy and imaging of melanin

M Wehbi, E Harkemanne, L Mignion, N Joudiou… - Molecular imaging and …, 2024 - Springer
The incidence of melanoma is continuously increasing over time. Melanoma is the most
aggressive skin cancer, significantly reducing quality of life and survival rates of patients at …

[HTML][HTML] Photoreactivity and phototoxicity of experimentally photodegraded hair melanosomes from individuals of different skin phototypes

K Mokrzyński, M Sarna, T Sarna - Journal of Photochemistry and …, 2023 - Elsevier
Even though melanin is commonly viewed as natural photoprotectant, the pigment
demonstrates residual photoreactivity, which under certain conditions could contribute to …