Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …

Gap junctions (GJs) formed by connexins (Cxs) play an important role in the intercellular
communication within most body tissues. In this paper, we focus on GJs and Cxs present in …

Purposes Gap junction intercellular communication (GJIC) is essential for articular cartilage
to respond appropriately to physical or biological stimuli and maintain homeostasis …

Objectives Connexin‐mediated functional gap junction intercellular communication (GJIC)
has a vital role in development, homeostasis and pathology. Transforming growth factor‐β1 …

Abstract Connexin 43 (Cx43)-mediated gap junction intercellular communication (GJIC)
plays a crucial role in the pathology and physiology of joint tissues. Transforming growth …

Intra-articular (IA) administration of drugs for the treatment of diseases such as rheumatoid
arthritis, osteoarthritis and psoriatic arthritis is a common strategy; however, the rapid …

Electron micrographs revealed the presence of gap junctions in osteoblastic cells over 40
years ago. These intercellular channels formed from connexins are present in bone forming …

Summary Objective Connexin (Cx) 43 hemichannels play a role in mechanotransduction.
This study was undertaken in order to determine if Cx43 hemichannels were activated in rat …

Chondrocytes in cartilage and bone cells population express connexin43 (Cx43) and gap
junction intercellular communication (GJIC) is essential to synchronize cells for coordinated …

BACKGROUND Intra-articular injection of local anaesthetics, opioids and corticosteroids is
frequently used to obtain perioperative analgesia following joint surgery. Although local …