[HTML][HTML] Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium: Integration of herbal medicine, enzyme engineering, and …

Y Lu, Q Luo, X Jia, JP Tam, H Yang, Y Shen… - Journal of Pharmaceutical …, 2023 - Elsevier
Flavonoids such as baohuoside I and icaritin are the major active compounds in Epimedii
Folium (EF) and possess excellent therapeutic effects on various diseases. Encouragingly …

[HTML][HTML] Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies

S Ben-Shabat, L Yarmolinsky, D Porat… - Drug delivery and …, 2020 - Springer
Viral infections affect three to five million patients annually. While commonly used antivirals
often show limited efficacy and serious adverse effects, herbal extracts have been in use for …

Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health

J Zhang, K Hu, L Di, P Wang, Z Liu, J Zhang… - Advanced drug delivery …, 2021 - Elsevier
Traditional herbal medicine (THM), an ancient science, is a gift from nature. For thousands of
years, it has helped humans fight diseases and protect life, health, and reproduction …

An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Y Xu, N Shrestha, V Préat, A Beloqui - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

[HTML][HTML] Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review

M Vertzoni, P Augustijns, M Grimm, M Koziolek… - European journal of …, 2019 - Elsevier
Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …

Predicting a Drug's Membrane Permeability: A Computational Model Validated With in Vitro Permeability Assay Data

BJ Bennion, NA Be, MW McNerney, V Lao… - The journal of …, 2017 - ACS Publications
Membrane permeability is a key property to consider during the drug design process, and
particularly vital when dealing with small molecules that have intracellular targets as their …

The biopharmaceutics classification system (BCS) and the biopharmaceutics drug disposition classification system (BDDCS): beyond guidelines

A Charalabidis, M Sfouni, C Bergström… - International journal of …, 2019 - Elsevier
The recent impact of the Biopharmaceutics Classification System (BCS) and the
Biopharmaceutics Drug Disposition Classification System (BDDCS) on relevant scientific …

A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

BFL Lai, RXZ Lu, L Davenport Huyer, S Kakinoki… - Nature protocols, 2021 - nature.com
Owing to their high spatiotemporal precision and adaptability to different host cells, organ-on-
a-chip systems are showing great promise in drug discovery, developmental biology studies …

Automated experimentation powers data science in chemistry

Y Shi, PL Prieto, T Zepel, S Grunert… - Accounts of Chemical …, 2021 - ACS Publications
Conspectus Data science has revolutionized chemical research and continues to break
down barriers with new interdisciplinary studies. The introduction of computational models …

Diffusion and Flux Improvement of Drugs through Complexation

MKC Mannava, A Garai, AK Nangia - Molecular Pharmaceutics, 2023 - ACS Publications
Improving the solubility and permeability of drugs via cocrystallization is an important theme
in crystal engineering with practical applications for the discovery and development of high …