Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …

Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the
development of modified drug delivery systems. They are widely known due to their …

A tri-fluid electrospinning process was successfully developed to prepare tri-chamber
complex nanofibers. The core–shell and Janus structure were combined to form a delicate …

Enteric polymers are widely used in amorphous solid dispersion (ASD) formulations. The
aim of the current study was to explore ASD failure mechanisms across a wide range of pH …

Weakly acid polymers with pH-responsive solubility are being used with increasing
frequency in amorphous solid dispersion (ASD) formulations of drugs with low aqueous …

Thermogravimetric analysis (TGA) is frequently used to define the threshold of acceptable
processing temperatures for hot melt extrusion. Herein, evaluation of chemical stability of …

Among the great number of poorly soluble drugs in pharmaceutical development, most of
them are weak bases. Typically, they readily dissolve in an acidic environment but are prone …

Stomach pH may vary following bariatric surgery, with implications for drug
delivery/bioavailability. Yet, this parameter has not been studied. In this work, gastric content …

Amorphous solid dispersions (ASDs) have been proven to increase the bioavailability of
poorly soluble drugs. It is desirable that the ASD provide a rapid dissolution rate and a …

Recent work has highlighted that amorphous solid dispersions (ASDs) containing
delamanid (DLM) and an enteric polymer, hypromellose phthalate (HPMCP), appear to be …