With the nucleus as an exception, mitochondria are the only animal cell organelles
containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte …

The follicle is the functional unit of the ovary, whereby ovarian development is largely
dependent on the development of the follicles themselves. The activation, growth, and …

STUDY QUESTION Are human ovarian aging and the age-related female fertility decline
caused by oxidative stress and mitochondrial dysfunction in oocytes? SUMMARY ANSWER …

The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …

Early embryonic arrest and fragmentation (EEAF) is a common phenomenon leading to
female infertility, but the genetic determinants remain largely unknown. The Moloney …

Fertilization by multiple sperm leads to lethal chromosomal number abnormalities, failed
embryo development, and miscarriage. In some vertebrate and invertebrate eggs, the so …

Mitochondrial dysfunction is widely implicated in various human diseases, through
mechanisms that go beyond mitochondria's well-established role in energy generation …

Oocyte quality is perhaps the most important limiting factor in female fertility; however, the
current methods of determining oocyte competence are only marginally capable of …

Highlights What are the main findings? For the first time, the in vitro effects of simulated
microgravity using a Random Positioning Machine on the ultrastructural features of human …

Background The oocyte and its surrounding cumulus cells (CCs) exist as an inseparable
entity. The maturation of the oocyte relies on communication between the oocyte and the …