Autophagy has emerged as a critical lysosomal pathway that maintains cell function and
survival through the degradation of cellular components such as organelles and proteins …

The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …

Autophagy regulates cell death both positively and negatively, but the molecular basis for
this paradox remains inadequately characterized. We demonstrate here that transient cell-to …

The global incidence of cancer and cancer‐related mortality is expected to rise in recent
years despite advancements in cancer diagnosis and therapeutics. Increasing evidences of …

Autophagy is an important cellular catabolic process that plays a variety of important roles,
including maintenance of the amino acid pool during starvation, recycling of damaged …

Autophagy is a catabolic pathway conserved among eukaryotes that allows cells to rapidly
eliminate large unwanted structures such as aberrant protein aggregates, superfluous or …

The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …

Autophagy is a cellular adaptive mechanism to stress, including that induced by
chemotherapeutic agents. Reverse phase protein array suggested that high expression of …

Objective Autophagy is an intracellular degradation pathway conserved in all eukaryotes
from yeast to humans. This process plays a quality‐control role by destroying harmful …

Quinacrine, also known as mepacrine, has originally been used as an antimalarial drug for
close to a century, but was recently rediscovered as an anticancer agent. The mechanisms …