The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas
XY Fu-Shin, PSY Lee, L Yang, N Gao, Y Zhang… - Progress in retinal and …, 2022 - Elsevier
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …
several underlying pathophysiological mechanisms, some of which are still uncertain. The …
[HTML][HTML] Extracellular vesicles: emerging tools as therapeutic agent carriers
Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …
[HTML][HTML] Diabetic retinopathy: Involved cells, biomarkers, and treatments
J Ren, S Zhang, Y Pan, M Jin, J Li, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR), a leading cause of vision loss and blindness worldwide, is
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …
[HTML][HTML] Corneal regeneration strategies: from stem cell therapy to tissue engineered stem cell scaffolds
M Wang, Y Li, H Wang, M Li, X Wang, R Liu… - Biomedicine & …, 2023 - Elsevier
Corneal epithelial defects and excessive wound healing might lead to severe complications.
As stem cells can self-renew infinitely, they are a promising solution for regenerating the …
As stem cells can self-renew infinitely, they are a promising solution for regenerating the …
[HTML][HTML] Research progress of exosomes in pathogenesis, diagnosis, and treatment of ocular diseases
X Feng, Z Peng, L Yuan, M Jin, H Hu, X Peng… - … in Bioengineering and …, 2023 - frontiersin.org
Exosomes are natural extracellular vesicles with a diameter of 30–150 nm, which exist in
biological fluids and contain biomolecules related to the parent cell, such as proteins …
biological fluids and contain biomolecules related to the parent cell, such as proteins …
[HTML][HTML] EndMT regulation by small RNAs in diabetes-associated fibrotic conditions: potential link with oxidative stress
Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and
atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ …
atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ …
[HTML][HTML] The CRISPR/Cas9 system delivered by extracellular vesicles
X Zhu, M Gao, Y Yang, W Li, J Bao, Y Li - Pharmaceutics, 2023 - mdpi.com
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) systems can precisely manipulate DNA sequences to change the …
protein (Cas) systems can precisely manipulate DNA sequences to change the …
[HTML][HTML] Selective drug delivery to the retinal cells: Biological barriers and avenues
E Ramsay, T Lajunen, M Bhattacharya… - Journal of Controlled …, 2023 - Elsevier
Retinal drug delivery is a challenging, but important task, because most retinal diseases are
still without any proper therapy. Drug delivery to the retina is hampered by the anatomical …
still without any proper therapy. Drug delivery to the retina is hampered by the anatomical …
Exosomes, extracellular vesicles and the eye
Exosomes are a subset of extracellular vesicles which accommodate a cargo of bioactive
biomolecules that generally includes proteins, nucleic acids, lipids, sugars, and related …
biomolecules that generally includes proteins, nucleic acids, lipids, sugars, and related …
[HTML][HTML] Extracellular-vesicle-based therapeutics in neuro-ophthalmic disorders
H Massoumi, S Amin, M Soleimani… - International Journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) have been recognized as promising candidates for developing
novel therapeutics for a wide range of pathologies, including ocular disorders, due to their …
novel therapeutics for a wide range of pathologies, including ocular disorders, due to their …