Tissue damage and inflammation are important triggers for regeneration and fibrosis. Tissue
damage not only induces inflammation in general, it also determines the type and …

Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …

Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte …

Radiotherapy induces and promotes innate and adaptive immunity in which host STING
plays an important role. However, radioresistance in irradiated tumors can also develop …

The current paradigm in macrophage biology is that some tissues mainly contain
macrophages from embryonic origin, such as microglia in the brain, whereas other tissues …

Chemokines are a family of cytokines that orchestrate the migration and positioning of
immune cells within tissues and are critical for the function of the immune system. CCR2 …

Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and
progressive disease with high mortality and limited therapeutic options. Excessive …

Renal fibrosis is a major hallmark of chronic kidney disease that is considered to be a
common end point of various types of renal disease. To date, the biological meaning of …

Background Activation of microglia and astrocytes, a prominent hallmark of both aging and
Alzheimer's disease (AD), has been suggested to contribute to aging and AD progression …

Interstitial lung fibrosis can develop as a consequence of occupational or medical exposure,
as a result of genetic defects, and after trauma or acute lung injury leading to …