Acute hypoxic–ischemic encephalopathy around the time of birth remains a major cause of
death and life-long disability. The key insight that led to the modern revival of studies of …

Abstract Purpose of Review Therapeutic hypothermia reduces death or disability in term and
near-term infants with moderate-severe hypoxic-ischemic encephalopathy. Nevertheless …

Importance Therapeutic hypothermia reduces risk of death and disability in infants with
moderate to severe hypoxic ischemic encephalopathy (HIE). Randomized clinical trials of …

Background Studies of early childhood outcomes of mild hypoxic-ischemic encephalopathy
(HIE) identified in the first 6 h of life are lacking. Objective To evaluate neurodevelopmental …

Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates
with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few …

Hypoxic-ischemic encephalopathy (HIE) is a major cause of neurological sequelae in (near-
) term newborns. Despite the use of therapeutic hypothermia, a significant number of …

Objectives To examine if therapeutic hypothermia reduces the composite outcome of death,
moderate or severe disability at 18 months or more after mild neonatal encephalopathy …

Context: Therapeutic hypothermia is the recommended treatment for neonates with
moderate or severe hypoxic ischemic encephalopathy (HIE). There is an increasing trend to …

Neonatal encephalopathy (NE) is a “clinical syndrome of disturbed neurologic function in the
first week after birth in an infant born at or beyond 35 weeks of gestation, manifest by a …

Background Mild hypoxic-ischemic encephalopathy (HIE) is increasingly recognized as a
risk factor for neonatal brain injury. We examined the timing and pattern of brain injury in …