Piperacillin/tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity encompassing most Gram-positive and Gram-negative …

Piperacillin–tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity that includes Gram-positive and-negative aerobic and …

Background: Recent studies have demonstrated highly variable blood concentrations of
piperacillin, tazobactam, cefepime, meropenem, ciprofloxacin and linezolid in critically ill …

Objectives: We investigated the population pharmacokinetics and pharmacodynamics of
piperacillin and tazobactam in hospitalized patients. Patients and methods: A multicentre …

Sepsis remains a major cause of mortality and morbidity in neonates, and, as a
consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient …

The selection of the right antibiotic and right dose necessitates clinicians understand the
contribution of pharmacokinetic variability stemming from age‐related physiologic …

Importance of the field: Piperacillin-tazobactam is a frequently prescribed intravenous
antibiotic for moderate to severe infections used in hospital settings because of its broad …

Piperacillin-tazobactam is often given to infants with severe infection in spite of limited
pharmacokinetics (PK) data. We evaluated piperacillin-tazobactam PK in premature and …

Abstract Background and Objective The use of an opportunistic (also called scavenged)
sampling strategy in a prospective pharmacokinetic study combined with population …

Methods: Blood samples (2–4 per child) were collected from 13 children ages 9 months to 6
years admitted to the pediatric intensive care unit who were receiving standard piperacillin …