The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Targeting TEAD autopalmitoylation has been proposed as a therapeutic approach for YAP-
dependent cancers. Here we show that TEAD palmitoylation inhibitor MGH-CP1 and …

MALAT1 has previously been described as a metastasis-promoting long noncoding RNA
(lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a …

YAP is a mechanosensitive transcriptional activator with a critical role in cancer,
regeneration, and organ size control. Here, we show that force applied to the nucleus …

Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

The expanding spectrum of both established and candidate oncogenic driver mutations
identified in non-small-cell lung cancer (NSCLC), coupled with the increasing number of …

YAP and TAZ are transcriptional activators pervasively induced in several human solid
tumours and their functions in cancer cells are the focus of intense investigation. These …

Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of
hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver …