Identification of epidermal growth factor receptor (EGFR) as a molecular target has radically
changed the treatment of metastatic non-small cell lung cancer (NSCLC) from standard …

Lung cancer remains a leading cause of mortality with 1.69 million deaths worldwide.
Activating mutations in epidermal growth factor receptor (EGFR), predominantly exon 19 …

Lung cancer often has a poor prognosis, with brain metastases a major reason for mortality.
We modified lonidamine (LND), an antiglycolytic drug with limited efficacy, to mitochondria …

Purpose While surgery and radiation remain the mainstays of therapy for all patients with
brain metastases (BM), the management is moving to a more individualized approach based …

Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors and has
high morbidity and mortality rates. Central nervous system (CNS) metastasis is one of the …

Abstract Purpose of Review Leptomeningeal disease (LMD) is a rare, late complication of
systemic cancer and is associated with significant neurological morbidity and high mortality …

OBJECTIVE Central nervous system (CNS) metastases include brain parenchymal, spinal
cord, and leptomeningeal metastases. This article discusses the diagnostic and therapeutic …

Abstract Lessons Learned This phase II trial evaluated the efficacy of erlotinib for patients
with non‐small cell lung cancer with leptomeningeal metastasis. The 17 cerebrospinal fluid …

驱动基因阳性非小细胞肺癌(non-small cell lung cancer, NSCLC) 脑转移是临床关注的热点,
综合治疗是原则, 不同治疗手段的合理组合和顺序安排, 对延长患者生存期和提高生活质量有着 …

Non-small cell lung cancer (NSCLC) is considered to be an inflammation-associated
carcinoma. Although interleukin‑17 (IL‑17) production contributes to the proliferation and …