Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Simple Summary There is no doubt that the need for new effective methods of cancer
treatment remains challenging, as cancer is the second cause of death based on the …

Aims Hypoxic–ischemic brain injury (HIBI) often results in cognitive impairments. Herein, we
investigated the roles of ferroptosis in HIBI and the underlying signaling pathways. Methods …

Mitochondria are double-membrane organelles that play a role in ATP synthesis, calcium
homeostasis, oxidation-reduction status, apoptosis, and inflammation. Several human …

Spatholobus suberectus Dunn (SSD) has been extensively employed in Traditional Chinese
Medicine to treat several ailments. SSD and its active compounds are effective therapeutic …

Intervertebral disc degeneration (IDD) is a common degenerative musculoskeletal disorder
and is recognized as a major contributor to discogenic lower back pain. However, the …

The primary objective of this study is to investigate the potential mechanism behind the
protective effect of Cistanche deserticola polysaccharides (CP) against alcoholic liver …

Despite significant advances in cancer therapeutics, chemotherapy remains the cornerstone
of treatment for many tumors. Importantly, however, chemotherapy-induced toxicity …

There is a vast pre-clinical literature suggesting that certain nutraceuticals have the potential
to aid the preservation of bone mass in the context of estrogen withdrawal, glucocorticoid …

The regulation of angiogenesis by nuclear factor erythroid 2-related factor 2 (Nrf2), a master
redox transcription factor, is well established. In the present study, we aimed to activate Nrf2 …