Humans and other mammals inhabit hypoxic high-altitude locales. In many of these species,
genes under positive selection include ones in the Hypoxia Inducible Factor (HIF) pathway …

The adaptation of Tibetans to high-altitude environments has been studied extensively.
However, the direct assessment of evolutionary adaptation, ie, the reproductive fitness of …

Background: Tibetans have lived at very high altitudes for thousands of years, and have a
distinctive suite of physiological traits that enable them to tolerate environmental hypoxia …

Compared with lowlander migrants, native Tibetans have a higher reproductive success at
high altitude though the underlying mechanism remains unclear. Here, we compared the …

Xining is located at the eastern edge of the Qinghai-Tibet Plateau, with an average altitude
of> 7000 feet (> 2000 m). Nalbuphine is a kappa-opioid receptor agonist that can provide …

Environmental hypoxia challenges female reproductive physiology in placental mammals,
increasing rates of gestational complications. Adaptation to high elevation has limited many …

Fetal growth and maturation are highly intertwined with placental development during
pregnancy. Here we used placental vascular morphology measurements (depth and span) …

The study aimed to evaluate the association between high-altitude polycythemia and
hypertension in adults residing on Anduo County's plateau, which is located 4700 meters …

目的探讨羟基脲(hydroxyurea, HU) 对密闭缺氧小鼠的保护作用及机制. 方法将60 只6~ 8 周龄,
体质量18~ 22 g 的雄性C57BL/6J 小鼠随机分成常氧对照组(NC 组, n= 10), 常氧HU 组(NHU …

Convergent adaptations represent paradigmatic examples of the capacity of natural
selection to influence organisms biology. However, the possibility to investigate genetic …