Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Studies of inflammatory bowel disease (IBD) have been inconclusive in relating microbiota
with distribution of inflammation. We report microbiota, host transcriptomics, epigenomics …

Nucleic acid is the main material for storing, copying, and transmitting genetic information.
Gene sequencing is of great significance in DNA damage research, gene therapy, mutation …

Inflammatory bowel disease (IBD) is a chronic relapsing–remitting systemic disease of the
gastrointestinal tract, characterized by an inflammatory process that requires lifelong …

Inflammatory bowel disease (IBD) is an immune-mediated disease of the intestinal tract, with
complex pathophysiology involving genetic, environmental, microbiome, immunological and …

With ageing, normal human tissues experience an expansion of somatic clones that carry
cancer mutations,,,,,–. However, whether such clonal expansion exists in the non-neoplastic …

Despite the growing knowledge surrounding host–microbiome interactions, we are just
beginning to understand how the gut microbiome influences—and is influenced by—host …

Recent progress in our understanding of the regulation of epithelial tissue stem cells has
allowed us to exploit their abilities and instruct them to self-organize into tissue-mimicking …