Non-Alcoholic Fatty Liver Disease or Type 2 Diabetes Mellitus—The Chicken or the Egg Dilemma

M Kosmalski, A Śliwińska, J Drzewoski - Biomedicines, 2023 - mdpi.com
In clinical practice, we often deal with patients who suffer from non-alcoholic fatty liver
disease (NAFLD) concurrent with type 2 diabetes mellitus (T2DM). The etiopathogenesis of …

[PDF][PDF] The global burden of metabolic disease: Data from 2000 to 2019

NWS Chew, CH Ng, DJH Tan, G Kong, C Lin, YH Chin… - Cell Metabolism, 2023 - cell.com
Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the
Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for …

New anti-diabetic agents for the treatment of non-alcoholic fatty liver disease: a systematic review and network meta-analysis of randomized controlled trials

T Kongmalai, V Srinonprasert… - Frontiers in …, 2023 - frontiersin.org
Objectives This network meta-analysis aims to compare the efficacy and safety of new anti-
diabetic medications for the treatment of non-alcoholic fatty liver disease (NAFLD). Materials …

Risk factors for cardiovascular disease in patients with metabolic-associated fatty liver disease: a machine learning approach

K Drożdż, K Nabrdalik, H Kwiendacz, M Hendel… - Cardiovascular …, 2022 - Springer
Background Nonalcoholic fatty liver disease is associated with an increased cardiovascular
disease (CVD) risk, although the exact mechanism (s) are less clear. Moreover, the …

[HTML][HTML] Type 2 diabetes mellitus in metabolic-associated fatty liver disease vs. type 2 diabetes mellitus non-alcoholic fatty liver disease: a longitudinal cohort analysis

M Muthiah, CH Ng, KE Chan, CE Fu, WH Lim… - Annals of …, 2023 - Elsevier
ABSTRACT Introduction and Objectives Type 2 Diabetes Mellitus (T2DM) is comorbidity
commonly presenting with fatty liver. A recently proposed definition of" metabolic associated …

[HTML][HTML] Hypertension is prevalent in non-alcoholic fatty liver disease and increases all-cause and cardiovascular mortality

CH Ng, ZY Wong, NWS Chew, KE Chan… - Frontiers in …, 2022 - frontiersin.org
Background & Aims: Hypertension (HTN) is a common comorbidity in non-alcoholic fatty
liver disease (NAFLD) affecting up to 40% of individuals. Yet, the impact of HTN and its …

MAFLD predicts cardiovascular disease risk better than MASLD

Z Pan, G Shiha, G Esmat, N Méndez‐Sánchez… - Liver …, 2024 - Wiley Online Library
Abstract Background and Aim Metabolic dysfunction‐associated steatotic liver disease
(MASLD) has been proposed as an alternative for the validated definition of metabolic …

Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long‐term mortality in acute myocardial infarction

YH Chin, J Lim, G Kong, CH Ng, R Goh… - Diabetes, Obesity …, 2023 - Wiley Online Library
Aim To examine the prevalence and prognosis of hepatic steatosis and fibrosis in post‐
acute myocardial infarction (AMI) patients. Methods Patients presenting with AMI to a tertiary …

Loss of metabolic adaptation in lean MAFLD is driven by endotoxemia leading to epigenetic reprogramming

J Alharthi, Z Pan, BS Gloss, D McLeod, M Weltman… - Metabolism, 2023 - Elsevier
Lean patients with MAFLD have an initial adaptive metabolic response characterised by
increased serum bile acids and Farnesoid X Receptor (FXR) activity. How this adaptive …

The spectrum and impact of metabolic dysfunction in MAFLD: A longitudinal cohort analysis of 32,683 overweight and obese individuals

KE Chan, CH Ng, CE Fu, J Quek, G Kong… - Clinical …, 2023 - Elsevier
Background Metabolic associated fatty liver disease (MAFLD) was recently proposed as an
alternative name change for better encapsulation of disease. However, there exists a …