OBJECTIVES: Natural history studies provide invaluable data on the disease course. First,
they help define the end points for clinical trials that are designed to test drugs for the end …

Crohn's disease (CD) is a chronic progressive destructive disease. Currently available
instruments measure disease activity at a specific point in time. An instrument to measure …

Background and Aims Inflammatory bowel diseases (IBD), encompassing Crohn's disease
(CD) and ulcerative colitis (UC), are chronic and disabling disorders. Prospective disease …

Background Objective control of intestinal inflammation during inflammatory bowel disease
(IBD) is becoming the main driver for medical treatment. However, the monitoring tools …

Objective The impact of inflammatory bowel disease (IBD) on disability remains poorly
understood. The World Health Organization's integrative model of human functioning and …

The Food and Drug Administration (FDA) is moving from the Crohn's Disease Activity Index
to patient-reported outcomes (PROs) and objective measures of disease, such as findings …

ICF Research Branch in cooperation with the WHO Collaborating Centre for the Family of
International Classifications in Germany (at DIMDI) Practical, standardized tools to assess …

OBJECTIVES: Magnetic resonance imaging (MRI) allows accurate assessment of Crohn's
disease (CD), but requires gadolinium injection. Diffusion-weighted (DW)-MRI yields …

Background & Aims Ustekinumab, a human monoclonal antibody against the p40 subunit of
interleukins-12 and-23, is effective in inducing and maintaining remission in patients with …

INTRODUCTION When Crohn and his colleagues first described regional ileitis in 1932, 1
intestinal resection was the only effective treatment available for these patients. Until the …