Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …

During the past two decades invasive fungal infections have emerged as major causes of
morbidity and mortality in immunocompromised patients. Several factors have contributed to …

In the murine model of Cryptococcus neoformans infection Th1 (IL-12/IFN-γ) and Th17 (IL-
23/IL-17) responses are associated with protection, whereas an IL-4-dependent Th2 …

To analyze the roles of interleukin-12 (IL-12) and the IL-12-dependent Th1 response in
resistance to Cryptococcus neoformans, we have established a chronic infection model in …

Pulmonary clearance of the encapsulated yeast Cryptococcus neoformans requires the
development of T1-type immunity. The objective of this study was to determine the role of …

Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a
wide range of infectious diseases. In several experimental models of bacterial, parasitic …

Interleukin-12 (IL-12) is a cytokine composed of two chains, a heavy chain or p40, and a
light chain or p35, forming a disulfite-linked heterodimer, or p70. IL-12 was originally …

Cryptococcosis is an important systemic mycosis and the third most prevalent disease in
human immunodeficiency virus (HIV)-positive individuals. The incidence of cryptococcosis is …

In recent years it has become evident that the structural polysaccharide chitin is synthesized
from a family of enzymes encoded by multiple CHS chitin synthase genes, and regulated by …

Macrophages are innate immune cells that possess unique abilities to polarize toward
different phenotypes. Classically activated macrophages are known to have major roles in …