Monocytes and macrophages: emerging mechanisms and novel therapeutic targets in Pulmonary Fibrosis

CY Perrot, T Karampitsakos… - American Journal of …, 2023 - journals.physiology.org
Pulmonary fibrosis results from a plethora of abnormal pathogenetic events. In idiopathic
pulmonary fibrosis (IPF), inhalational, environmental, or occupational exposures in …

Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways

W Luo, Y Gu, S Fu, J Wang, J Zhang, Y Wang - European Journal of …, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …

[HTML][HTML] Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open label, randomized controlled trial

T Karampitsakos, O Papaioannou, P Tsiri… - Clinical Microbiology …, 2023 - Elsevier
Objective Randomized controlled trials comparing tocilizumab and baricitinib in patients with
coronavirus disease 2019 (COVID-19) are needed. This was an open-label, randomized …

[HTML][HTML] Post-COVID-19 interstitial lung disease: Insights from a machine learning radiographic model

T Karampitsakos, V Sotiropoulou, M Katsaras… - Frontiers in …, 2023 - frontiersin.org
Introduction Post-acute sequelae of COVID-19 seem to be an emerging global crisis.
Machine learning radiographic models have great potential for meticulous evaluation of post …

[HTML][HTML] The role of autotaxin and LPA signaling in embryonic development, pathophysiology and cancer

C Magkrioti, E Kaffe, V Aidinis - International Journal of Molecular …, 2023 - mdpi.com
Autotaxin (ATX) or Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a
secreted enzyme with lysophospholipase D activity, with its primary function being the …

[HTML][HTML] Tocilizumab improves 28-day survival in hospitalized patients with severe COVID-19: an open label, prospective study

T Karampitsakos, E Malakounidou, O Papaioannou… - Respiratory …, 2021 - Springer
Background Data on the safety and efficacy profile of tocilizumab in patients with severe
COVID-19 needs to be enriched. Methods In this open label, prospective study, we …

[HTML][HTML] Immune-mediated lung diseases: A narrative review

JJG Sweis, NWG Sweis, F Alnaimat, J Jansz… - Frontiers in …, 2023 - frontiersin.org
The role of immunity in the pathogenesis of various pulmonary diseases, particularly
interstitial lung diseases (ILDs), is being increasingly appreciated as mechanistic …

[HTML][HTML] Mechanism of COVID-19 causing ARDS: Exploring the possibility of preventing and treating SARS-CoV-2

J Zheng, J Miao, R Guo, J Guo, Z Fan… - Frontiers in Cellular …, 2022 - frontiersin.org
Novel coronavirus pneumonia (COVID-19) is spreading worldwide, causing great harm and
stress to humans. Since patients with novel coronavirus (SARS-CoV-2) have a high …

[HTML][HTML] Autotaxin has a negative role in systemic inflammation

I Nikitopoulou, A Katsifa, P Kanellopoulou… - International Journal of …, 2022 - mdpi.com
The pathogenesis of sepsis involves complex interactions and a systemic inflammatory
response leading eventually to multiorgan failure. Autotaxin (ATX, ENPP2) is a secreted …

Novel 3D-based deep learning for classification of acute exacerbation of idiopathic pulmonary fibrosis using high-resolution CT

X Huang, W Si, X Ye, Y Zhao, H Gu… - BMJ Open …, 2024 - bmjopenrespres.bmj.com
Purpose Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is the primary cause of
death in patients with IPF, characterised by diffuse, bilateral ground-glass opacification on …