Monocytes and macrophages: emerging mechanisms and novel therapeutic targets in Pulmonary Fibrosis
CY Perrot, T Karampitsakos… - American Journal of …, 2023 - journals.physiology.org
Pulmonary fibrosis results from a plethora of abnormal pathogenetic events. In idiopathic
pulmonary fibrosis (IPF), inhalational, environmental, or occupational exposures in …
pulmonary fibrosis (IPF), inhalational, environmental, or occupational exposures in …
Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways
Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
[HTML][HTML] Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open label, randomized controlled trial
T Karampitsakos, O Papaioannou, P Tsiri… - Clinical Microbiology …, 2023 - Elsevier
Objective Randomized controlled trials comparing tocilizumab and baricitinib in patients with
coronavirus disease 2019 (COVID-19) are needed. This was an open-label, randomized …
coronavirus disease 2019 (COVID-19) are needed. This was an open-label, randomized …
[HTML][HTML] Post-COVID-19 interstitial lung disease: Insights from a machine learning radiographic model
T Karampitsakos, V Sotiropoulou, M Katsaras… - Frontiers in …, 2023 - frontiersin.org
Introduction Post-acute sequelae of COVID-19 seem to be an emerging global crisis.
Machine learning radiographic models have great potential for meticulous evaluation of post …
Machine learning radiographic models have great potential for meticulous evaluation of post …
[HTML][HTML] The role of autotaxin and LPA signaling in embryonic development, pathophysiology and cancer
C Magkrioti, E Kaffe, V Aidinis - International Journal of Molecular …, 2023 - mdpi.com
Autotaxin (ATX) or Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a
secreted enzyme with lysophospholipase D activity, with its primary function being the …
secreted enzyme with lysophospholipase D activity, with its primary function being the …
[HTML][HTML] Tocilizumab improves 28-day survival in hospitalized patients with severe COVID-19: an open label, prospective study
T Karampitsakos, E Malakounidou, O Papaioannou… - Respiratory …, 2021 - Springer
Background Data on the safety and efficacy profile of tocilizumab in patients with severe
COVID-19 needs to be enriched. Methods In this open label, prospective study, we …
COVID-19 needs to be enriched. Methods In this open label, prospective study, we …
[HTML][HTML] Immune-mediated lung diseases: A narrative review
The role of immunity in the pathogenesis of various pulmonary diseases, particularly
interstitial lung diseases (ILDs), is being increasingly appreciated as mechanistic …
interstitial lung diseases (ILDs), is being increasingly appreciated as mechanistic …
[HTML][HTML] Mechanism of COVID-19 causing ARDS: Exploring the possibility of preventing and treating SARS-CoV-2
J Zheng, J Miao, R Guo, J Guo, Z Fan… - Frontiers in Cellular …, 2022 - frontiersin.org
Novel coronavirus pneumonia (COVID-19) is spreading worldwide, causing great harm and
stress to humans. Since patients with novel coronavirus (SARS-CoV-2) have a high …
stress to humans. Since patients with novel coronavirus (SARS-CoV-2) have a high …
[HTML][HTML] Autotaxin has a negative role in systemic inflammation
I Nikitopoulou, A Katsifa, P Kanellopoulou… - International Journal of …, 2022 - mdpi.com
The pathogenesis of sepsis involves complex interactions and a systemic inflammatory
response leading eventually to multiorgan failure. Autotaxin (ATX, ENPP2) is a secreted …
response leading eventually to multiorgan failure. Autotaxin (ATX, ENPP2) is a secreted …
Novel 3D-based deep learning for classification of acute exacerbation of idiopathic pulmonary fibrosis using high-resolution CT
X Huang, W Si, X Ye, Y Zhao, H Gu… - BMJ Open …, 2024 - bmjopenrespres.bmj.com
Purpose Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is the primary cause of
death in patients with IPF, characterised by diffuse, bilateral ground-glass opacification on …
death in patients with IPF, characterised by diffuse, bilateral ground-glass opacification on …