Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …

Lang, Florian, Gillian L. Busch, Markus Ritter, Harald Völkl, Siegfried Waldegger, Erich
Gulbins, and Dieter Häussinger. Functional Significance of Cell Volume Regulatory …

The discovery of oxygen is considered by some to be the most important scientific discovery
of all time—from both physical–chemical/astrophysics and biology/evolution viewpoints. One …

The fact that metabolic rate scales as the three-quarter power of body mass (M) in
unicellular, as well as multicellular, organisms suggests that the same principles of …

Radiotherapy and chemotherapy are given in multiple doses, which are spaced out to allow
the recovery of normal tissues between treatments. However, surviving cancer cells also …

This article reviews actual advances in the development and application of three-
dimensional (3-D) cell culture systems. Recent therapeutically oriented studies include …

Purpose: To give a state-of-the-art overview on the promise of three-dimensional (3-D)
culture systems for anticancer drug development, with particular emphasis on multicellular …

Mathematical modeling, analysis and simulation are set to play crucial roles in explaining
tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial …

The growth of tumour cells as three‐dimensional multicellular spheroids in vitro has led to
important insights in tumour biology, since properties of the in vivo‐tumour such as …

The growth and development of solid tumours occurs in two distinct stages—the avascular
growth phase and the vascular growth phase. During the former growth phase the tumour …