[HTML][HTML] Porphyromonas gingivalis FimA and Mfa1 fimbriae: Current insights on localization, function, biogenesis, and genotype

Y Hasegawa, K Nagano - Japanese Dental Science Review, 2021 - Elsevier
In general, the periodontal pathogen Porphyromonas gingivalis expresses distinct FimA and
Mfa1 fimbriae. Each of these consists of five FimA–E and five Mfa1–5 proteins encoded by …

An investigation into the effects of outer membrane vesicles and lipopolysaccharide of Porphyromonas gingivalis on blood-brain barrier integrity, permeability, and …

AB Pritchard, Z Fabian, CL Lawrence… - Journal of …, 2022 - content.iospress.com
Background: The effects of the key pathogens and virulence factors associated with gum
disease such as Porphyromonas gingivalis (P. gingivalis) on the central nervous system is of …

Periodontitis associates with species-specific gene expression of the oral microbiota

D Belstrøm, F Constancias, DI Drautz-Moses… - npj Biofilms and …, 2021 - nature.com
The purpose of the present investigation was to characterize species-specific bacterial
activity of the oral microbiota in periodontitis. We tested the hypotheses that chronic …

[HTML][HTML] Porphyromonas gingivalis outer membrane vesicles modulate cytokine and chemokine production by gingipain-dependent mechanisms in human …

Y Castillo, JE Castellanos, GI Lafaurie… - Archives of oral biology, 2022 - Elsevier
Objective The aim was to determine the changes of inflammatory mediator expression in
human macrophages stimulated with outer membrane vesicles purified from …

Exploring the genetic and functional diversity of Porphyromonas gingivalis long fimbriae

HL Meyer, MMH Abdelbary, EM Buhl… - Molecular Oral …, 2023 - Wiley Online Library
Porphyromonas gingivalis is a key pathobiont in periodontitis. Its long fimbriae consist of a
single anchor (FimB), a varying number of stalk (FimA), and three accessory (tip‐related) …

A quantitative framework reveals traditional laboratory growth is a highly accurate model of human oral infection

GR Lewin, KS Stocke, RJ Lamont… - Proceedings of the …, 2022 - National Acad Sciences
Bacterial behavior and virulence during human infection is difficult to study and largely
unknown, as our vast knowledge of infection microbiology is primarily derived from studies …

Strain-level variation and diverse host bacterial responses in episymbiotic Saccharibacteria

J Nie, DR Utter, KA Kerns, EI Lamont, EL Hendrickson… - Msystems, 2022 - Am Soc Microbiol
ABSTRACT Saccharibacteria (TM7), which are obligate episymbionts growing on the
surface of host bacteria, may play an important role in oral disease, such as periodontitis (1 …

Comparative analysis of Porphyromonas gingivalis A7436 and ATCC 33277 strains reveals differences in the expression of heme acquisition systems

M Śmiga, P Ślęzak, T Olczak - Microbiology Spectrum, 2024 - Am Soc Microbiol
Porphyromonas gingivalis strains exhibit different phenotypes in vitro, different virulence
potential in animal models, and different associations with human diseases, with strains …

Inhibitory effect of Porphyromonas gingivalis‐derived phosphoethanolamine dihydroceramide on acid ceramidase expression in oral squamous cells

C Yamada, A Ho, A Nusbaum, R Xu… - Journal of Cellular …, 2023 - Wiley Online Library
The maintenance of diminished acid ceramidase (ASAH1) gene expression leading to the
accumulation of antiproliferative intracellular ceramides in oral squamous cell carcinoma …

Nicotinamide employs a starvation strategy against Porphyromonas gingivalis virulence by inhibiting the heme uptake system and gingipain activities

Z Lei, Q Ma, Y Tu, Y Qiu, T Gong, Y Lin… - Molecular Oral …, 2024 - Wiley Online Library
Periodontitis is a common oral bacterial infection characterized by inflammatory responses.
Its high prevalence lowers the quality of life for individuals and increases the global …