Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant
non-collagenous protein in bone, was demonstrated to inhibit bone formation and function …

The Mouse Metabolic Phenotyping Center (MMPC) Consortium was established to address
the need to characterize the growing number of mouse models of metabolic diseases …

Mitochondria are critical for respiration in all tissues; however, in liver, these organelles also
accommodate high-capacity anaplerotic/cataplerotic pathways that are essential to …

The liver plays a crucial role in mobilizing energy during nutritional deprivation. During the
early stages of fasting, hepatic glycogenolysis is a primary energy source. As fasting …

The liver has a central role in the regulation of systemic glucose and lipid fluxes during
feeding and fasting and also relies on these substrates for its own energy needs. These …

The manner in which insulin resistance impinges on hepatic mitochondrial function is
complex. Although liver insulin resistance is associated with respiratory dysfunction, the …

The pathophysiology of diabetes as a disease is characterised by an inability to maintain
normal glucose homeostasis. In type 1 diabetes, this is due to autoimmune destruction of the …

The hepatic tricarboxylic acid (TCA) cycle is central to integrating macronutrient metabolism
and is closely coupled to cellular respiration, free radical generation, and inflammation …

The incidence of insulin resistance and type 2 diabetes (T2D) is increasing at alarming
rates. In the quest to understand the underlying causes of and to identify novel therapeutic …

OBJECTIVE—To characterize differences in whole-body glucose metabolism between
commonly used inbred mouse strains. RESEARCH DESIGN AND METHODS …