Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Osteoporosis is characterized by the alteration of bone homeostasis due to an imbalance
between osteoclastic bone resorption and osteoblastic bone formation. Estrogen deficiency …

Novel tissue regeneration strategies are constantly being developed worldwide. Research
on bone regeneration is noteworthy, as many promising new approaches have been …

The importance of the kynurenine pathway in normal immune system function has led to an
appreciation of its possible contribution to autoimmune disorders such as rheumatoid …

Osteoimmunology is the interdiscipline that focuses on the relationship between the skeletal
and immune systems. They are interconnected by shared signal pathways and cytokines …

Discoveries in the last few years have emphasized the existence of an enormous breadth of
communication between bone and the immune system in maintaining skeletal homeostasis …

Formation of mature bone-resorbing cells through osteoclastogenesis is required for the
continuous remodeling and repair of bone tissue. In aging and disease this process may …

Purpose The dietary inflammatory index (DII) is a scoring system to quantify the inflammatory
effects of nutrients and foods. Inflammation may affect bone health. The purpose of this study …

The imbalance induced by inhibition of bone mesenchymal stem cell (BMSC) osteogenic
differentiation results in osteoporosis (OP); however, the underlying regulatory mechanism is …

The IDO/kynurenine pathway is now established as a major regulator of immune system
function. The initial enzyme, indoleamine 2, 3-dioxygenase (IDO1) is induced by IFNγ, while …