Background Pain is reported as the leading cause of disability in the common forms of
inflammatory arthritis conditions. Acting as a key player in nociceptive processing …

A significant number of experimental and clinical studies published in peer-reviewed
journals have demonstrated promising pharmacological properties of capsaicin in relieving …

Chronic pain, when not effectively treated, is a leading health and socioeconomic problem
and has a harmful effect on all aspects of health-related quality of life. Therefore …

The temporomandibular joint (TMJ) undergoes degenerative changes among patients who
suffer from arthritis, and yet the pathogenesis of TMJ osteoarthritis and rheumatoid arthritis is …

While proteases are essential in gastrointestinal physiology, accumulating evidence
indicates that dysregulated proteolysis plays a pivotal role in the pathophysiology of …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation in the
joints. Although methotrexate (MX) is the first-line treatment, side effects are common. This …

Background and purpose: Recent findings suggest that the noxious gas H2S is produced
endogenously, and that physiological concentrations of H2S are able to modulate pain and …

The complement system significantly contributes to the development of inflammatory and
neuropathic pain, but the underlying mechanisms are poorly understood. Recently, we …

There is accumulating evidence that substance P released from peripheral sensory neurons
participates in inflammatory and neuropathic pain. In this study it was investigated the ability …

Seaweed lectins have been widely investigated as anti-nociceptive and anti-inflammatory
agents. This study analyzed the anti-nociceptive and anti-inflammatory responses of a lectin …