Nonalcoholic steatohepatitis: global impact and clinical consequences

K Kabarra, P Golabi, ZM Younossi - Endocrine connections, 2021 - ec.bioscientifica.com
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver diseases ranging
from simple fatty infiltration of liver parenchyma to the potentially progressive type of NAFLD …

Crocin inhibits angiogenesis and metastasis in colon cancer via TNF-α/NF-kB/VEGF pathways

HA Bakshi, GA Quinn, MM Nasef, V Mishra… - Cells, 2022 - mdpi.com
Angiogenesis and metastasis play pivotal roles in the progression of cancer. We recently
discovered that crocin, a dietary carotenoid derived from the Himalayan crocus, inhibited the …

Recent advances in mesoporous silica nanoparticles delivering siRNA for cancer treatment

X Xie, T Yue, W Gu, WY Cheng, L He, WY Ren, F Li… - Pharmaceutics, 2023 - mdpi.com
Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer.
However, the curative effect of siRNA is severely constrained by low serum stability and cell …

[HTML][HTML] Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling

S Saber, EE Abd El-Fattah, AM Abdelhamid… - Biomedicine & …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the third foremost cause of cancer-related deaths. HCC
has a very bad prognosis because it is asymptomatic in the early stages, resulting in a late …

Preparation, characterization and in vitro anticancer efficacy of biotin-conjugated, silibinin loaded bovine serum albumin nanoparticles

R Solanki, S Patel - Food Bioscience, 2023 - Elsevier
Silibinin (SBN) is a natural, plant-derived bioactive flavonolignan, possessing wide range of
pharmaceutical activities including anticancer. However, poor aqueous solubility and low …

Combination of Panax ginseng CA Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

HM Al-Kuraishy, HA Al-Hussaniy… - Frontiers in …, 2022 - frontiersin.org
Doxorubicin (DOX) is an anticancer agent for treating solid and soft tissue malignancies.
However, the clinical use of DOX is restricted by cumulative, dose-dependent cardiotoxicity …

LncRNA HOTAIRM1 promotes dental follicle stem cell‐mediated bone regeneration by regulating HIF‐1α/KDM6/EZH2/H3K27me3 axis

Z Chen, L Gan, X Chen, J Zheng, S Shi… - Journal of Cellular …, 2023 - Wiley Online Library
Large bone defect reconstruction undergoes hypoxia and remains a major practical
challenge. Bone tissue engineering with a more promising stem cell source facilitates the …

Prosopis juliflora (Sw.) DC phytochemicals induce apoptosis and inhibit cell proliferation signaling pathways, EMT, migration, invasion, angiogenesis and stem cell …

J Choudhari, R Nimma, SK Nimal, SKT Venkata… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Prosopis juliflora (Sw.), DC is a xerophytic plant
species that extensively grow in Asia, Africa, Australia, and Brazil. From ancient time P …

Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation

M Yu, H Li, B Wang, Z Wu, S Wu, G Jiang… - Chemico-Biological …, 2023 - Elsevier
The polypeptide antibiotic Polymyxin B (PMB) can cause acute kidney injury (AKI), we found
that ferroptosis is one of the main mechanisms of renal injury caused by PMB. It was …

Determination of Therapeutic and Safety Effects of Zygophyllum coccineum Extract in Induced Inflammation in Rats

M Yosri, MM Elaasser, MM Abdel-Aziz… - BioMed Research …, 2022 - Wiley Online Library
Background. Z. coccineum is a facultative plant with many medicinal applications. This study
examined the anti‐inflammatory activity of Zygophyllum coccineum (Z. coccineum) in an …