Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

Inherited retinal disease is a common cause of visual impairment and represents a highly
heterogeneous group of conditions. Here, we present findings from a cohort of 722 …

Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …

Sensorineural hearing impairment is the most common form of hearing loss, and
encompasses pathologies of the cochlea and the auditory nerve. Hearing impairment …

Scurfy (sf) is an X-linked recessive mouse mutant resulting in lethality in hemizygous males
16–25 days after birth, and is characterized by overproliferation of CD4+ CD8–T …

Congenital stationary night blindness (CSNB) refers to a group of genetically and clinically
heterogeneous retinal disorders. Seventeen different genes with more than 360 different …

▪ Abstract Voltage-gated Ca2+ channels mediate Ca2+ entry into cells in response to
membrane depolarization. Electrophysiological studies reveal different Ca2+ currents …

During the last two to three decades, a large body of work has revealed the molecular basis
of many human disorders, including retinal and vitreoretinal degenerations and …

Abstract Ca V 1.2, the cardiac L-type calcium channel, is important for excitation and
contraction of the heart. Its role in other tissues is unclear. Here we present Timothy …