In vitro metabolism of the lignan (−)‐grandisin, an anticancer drug candidate, by human liver microsomes

T Barth, MD Habenschus, F Lima Moreira… - Drug Testing and …, 2015 - Wiley Online Library
(−)‐grandisin is a tetrahydrofuran lignan that displays important biological properties, such
as trypanocidal, anti‐inflammatory, cytotoxic, and antitumor activities, suggesting its utility as …

Essential Oil Constituents of Piper vicosanum Yunker from the Brazilian Atlantic Forest

JMO Mesquita, AB Oliveira, FC Braga… - Journal of Essential …, 2006 - Taylor & Francis
The composition of Piper vicosanum Yuncker leaf essential oil from the Brazilian Atlantic
Forest (Parque Estadual do Rio Doce, Minas Gerais, Brazil) was investigated. GC and …

Caldensinic acid, a prenylated benzoic acid from Piper caldense

GC Freitas, ROS Kitamura, JHG Lago, MCM Young… - Phytochemistry …, 2009 - Elsevier
The CH2Cl2 and MeOH extracts from leaves of Piper caldense were subjected to
chromatographic separation procedures to afford the new prenylated benzoic acid …

Chemoprotective effect of the tetrahydrofuran lignan grandisin in the in-vivo rodent micronucleus assay

MC Valadares, LM de Oliveira Júnior… - Journal of Pharmacy …, 2011 - academic.oup.com
Objectives The chemoprotective effect of the tetrahydrofuran lignan grandisin against DNA
damage induced by cyclophosphamide (200 mg/kg) has been evaluated using the in vitro …

[PDF][PDF] Efecto de los extractos de hojas de plantas sobre los parámetros fisiológicos y la microbiología intestinal de pollos parrilleros

X Beteta Blas - 2023 - repositorio.unas.edu.pe
En la actualidad, los residuos de antibióticos en alimentos de origen animal, la resistencia
antimicrobiana de microorganismos, la amplia demanda de fármacos veterinarios, el …

Disruption of Chrysomya megacephala Growth Caused by Lignan Grandisin

CDR Nogueira, RP De Mello, MJ Kato… - Journal of medical …, 2009 - academic.oup.com
The toxicity of tetrahydrofuran lignan grandisin was evaluated against larvae of Chrysomya
megacephala F.(Diptera: Calliphoridae). The bioassay involved topical treatment on larvae …

[引用][C] 石蝉草中的一个新四氢呋喃木脂素(英文)

孙若峰, 杨郁, 徐锐, 赵毅民, 于能江 - 国际药学研究杂志, 2016

[PDF][PDF] Antitrypanosomal agents from higher plants

WN Setzer, MC Setzer - Biologically active natural products for the …, 2006 - researchgate.net
Parasitic protozoal infections such as trypanosomiasis continue to be a great cause of
human morbidity and mortality. African sleeping sickness (African trypanosomiasis) is a re …

[HTML][HTML] Grandisin induces apoptosis in leukemic K562 cells

AP Cortez, EGP Menezes, PL Benfica… - Brazilian Journal of …, 2017 - SciELO Brasil
In this study, the potential antileukemic activity of grandisin, a lignan extracted from Piper
solmsianum, was evaluated against the leukemic line K562. The cytotoxicity of grandisin …

Six New Phenolic Glycosides and a New Ceramide from the Flowers of Wedelia biflora and Their Cytotoxicity Against Some Cancer Cell Lines

NTH Thu, LT Ha, VT Nga, PNK Tuyen… - Natural product …, 2013 - journals.sagepub.com
The plant Wedelia biflora has been used in traditional medicine in India and Vietnam to treat
various symptoms. However, the chemical composition of its flowers remains mostly …