The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …

The transition from acute to chronic pain is critically important but not well understood. Here,
we investigated the pathophysiological mechanisms underlying the transition from acute to …

Inflammation is the body's response to injury and infection, involving a complex biological
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …

Chronic pain is a critical clinical problem with an increasing prevalence. However, there are
limited effective prevention measures and treatments for chronic pain. Astrocytes are the …

Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …

Migraine is a prevalent disorder, affecting 15.1% of the world's population. In most cases, the
migraine attacks are sporadic; however, some individuals experience a gradual increase in …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Objective To describe the clinical data from the first 108 patients seen in the Mayo Clinic
post–COVID-19 care clinic (PCOCC). Methods After Institutional Review Board approval, we …

Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute
and chronic pain states, especially in acute postoperative and chronic neuropathic pain …