Migraine is a common and disabling primary headache disorder with a significant
socioeconomic burden. The management of migraine is multifaceted and is generally …

Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …

Human cytochrome P450 1A2 (CYP1A2) is one of the major CYPs in the liver (&sim13%)
and metabolizes about 20% of clinically used drugs. CYP1A2 is a 515-residue protein with a …

The low bioavailability of the anti‐migraine drug sumatriptan is partially caused by first‐pass
hepatic metabolism. In this study, we analyzed the impact of the hepatic organic cation …

Background and Objectives Sex hormones may modulate calcitonin gene-related peptide
(CGRP) release in the trigeminovascular system. We studied CGRP concentrations in …

The drug-metabolizing enzymes that contribute to the metabolism or bioactivation of a drug
play a crucial role in defining the absorption, distribution, metabolism, and excretion …

The effects of percutaneous enhancers on the transdermal absorption of sumatriptan
succinate were investigated by in vitro permeation studies. Pretreatment of porcine skin with …

In-vitro permeation studies were conducted to assess the feasibility of fabricating dissolving-
microneedle-array systems to release sumatriptan succinate. The formulations consisted …

The volume of distribution (VD) in humans of 179 known drug molecules (acids, bases, and
neutrals) has been modeled using two biomimetic-binding measurements. The phospholipid …

Psychoactive drugs of fungal origin, psilocin, ibotenic acid, and muscimol among them have
been proposed for recreational use and popularized since the 1960s, XX century. Despite …