The emerging role of Raman spectroscopy as an omics approach for metabolic profiling and biomarker detection toward precision medicine

G Cutshaw, S Uthaman, N Hassan… - Chemical …, 2023 - ACS Publications
Omics technologies have rapidly evolved with the unprecedented potential to shape
precision medicine. Novel omics approaches are imperative toallow rapid and accurate data …

Recent application of Raman spectroscopy in tumor diagnosis: from conventional methods to artificial intelligence fusion

Y Qi, Y Liu, J Luo - PhotoniX, 2023 - Springer
Raman spectroscopy, as a label-free optical technology, has widely applied in tumor
diagnosis. Relying on the different Raman technologies, conventional diagnostic methods …

Unveiling cancer metabolism through spontaneous and coherent Raman spectroscopy and stable isotope probing

J Xu, T Yu, CE Zois, JX Cheng, Y Tang, AL Harris… - Cancers, 2021 - mdpi.com
Simple Summary Raman spectroscopy and imaging are label-free, non-destructive
techniques to study cellular metabolism with subcellular spatial resolution. This review …

Living sample viability measurement methods from traditional assays to nanomotion

H Al-Madani, H Du, J Yao, H Peng, C Yao, B Jiang… - Biosensors, 2022 - mdpi.com
Living sample viability measurement is an extremely common process in medical,
pharmaceutical, and biological fields, especially drug pharmacology and toxicology …

Stimulated Raman scattering microscopy with spectral phasor analysis: applications in assessing drug–cell interactions

WJ Tipping, LT Wilson, C An, AA Leventi, AW Wark… - Chemical …, 2022 - pubs.rsc.org
Statins have displayed significant, although heterogeneous, anti-tumour activity in breast
cancer disease progression and recurrence. They offer promise as a class of drugs …

First Trimester Prediction of Preterm Birth in Patient Plasma with Machine-Learning-Guided Raman Spectroscopy and Metabolomics

L Synan, S Ghazvini, S Uthaman… - … Applied Materials & …, 2023 - ACS Publications
Preterm birth (PTB) is the leading cause of infant deaths globally. Current clinical measures
often fail to identify women who may deliver preterm. Therefore, accurate screening tools are …

Variabilities in global DNA methylation and β-sheet richness establish spectroscopic landscapes among subtypes of pancreatic cancer

K Szymoński, E Lipiec, K Sofińska… - European Journal of …, 2023 - Springer
Purpose Knowledge about pancreatic cancer (PC) biology has been growing rapidly in
recent decades. Nevertheless, the survival of PC patients has not greatly improved. The …

Metabolic Response to Small Molecule Therapy in Colorectal Cancer Tracked with Raman Spectroscopy and Metabolomics

G Cutshaw, N Joshi, X Wen, E Quam… - Angewandte Chemie …, 2024 - Wiley Online Library
Despite numerous screening tools for colorectal cancer (CRC), 25% of patients are
diagnosed with advanced disease. Novel diagnostic technologies that are early, accurate …

Quantitative Raman chemical imaging of intracellular drug-membrane aggregates and small molecule drug precipitates in cytoplasmic organelles

V LaLone, D Smith, J Diaz-Espinosa… - Advanced Drug Delivery …, 2023 - Elsevier
Raman confocal microscopes have been used to visualize the distribution of small molecule
drugs within different subcellular compartments. This visualization allows the discovery …

Recent Contributions of Mass Spectrometry-Based “Omics” in the Studies of Breast Cancer

S Banerjee, M Hatimuria, K Sarkar, J Das… - Chemical Research …, 2023 - ACS Publications
Breast cancer (BC) is one of the most heterogeneous groups of cancer. As every biotype of
BC is unique and presents a particular “omic” signature, they are increasingly characterized …