Anti-double stranded DNA antibodies: origin, pathogenicity, and targeted therapies
X Wang, Y Xia - Frontiers in immunology, 2019 - frontiersin.org
Systemic lupus erythematosus (SLE) is characterized by high-titer serological
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …
Systemic lupus erythematosus and cardiovascular disease
J Frostegård - Journal of Internal Medicine, 2023 - Wiley Online Library
The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment
and care, but cardiovascular disease (CVD) still remains an important clinical problem, since …
and care, but cardiovascular disease (CVD) still remains an important clinical problem, since …
B cells and humoral immunity in atherosclerosis
Insights into the important contribution of inflammation and immune functions in the
development and progression of atherosclerosis have greatly improved our understanding …
development and progression of atherosclerosis have greatly improved our understanding …
Protective roles of natural IgM antibodies
C Grönwall, J Vas, GJ Silverman - Frontiers in immunology, 2012 - frontiersin.org
Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-
tuning of the recognition and response to foreign threats. However, in health there are some …
tuning of the recognition and response to foreign threats. However, in health there are some …
Autoantibodies in SLE: specificities, isotypes and receptors
B Dema, N Charles - Antibodies, 2016 - mdpi.com
Systemic Lupus Erythematosus (SLE) is characterized by a wide spectrum of auto-
antibodies which recognize several cellular components. The production of these self …
antibodies which recognize several cellular components. The production of these self …
Antinuclear autoantibodies in health: autoimmunity is not a synonym of autoimmune disease
IA Pashnina, IM Krivolapova, TV Fedotkina… - Antibodies, 2021 - mdpi.com
The incidence of autoimmune diseases is increasing. Antinuclear antibody (ANA) testing is a
critical tool for their diagnosis. However, ANA prevalence in healthy persons has increased …
critical tool for their diagnosis. However, ANA prevalence in healthy persons has increased …
Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody
D Frescas, CM Roux, S Aygun-Sunar… - Proceedings of the …, 2017 - National Acad Sciences
Studying the phenomenon of cellular senescence has been hindered by the lack of
senescence-specific markers. As such, detection of proteins informally associated with …
senescence-specific markers. As such, detection of proteins informally associated with …
C1q and HMGB1 reciprocally regulate human macrophage polarization
M Son, A Porat, M He, J Suurmond… - Blood, The Journal …, 2016 - ashpublications.org
A healthy immune system results from a balance of stimulatory and inhibitory pathways that
allow effective responses to acute insults, without descending into chronic inflammation …
allow effective responses to acute insults, without descending into chronic inflammation …
Natural antibodies–facts known and unknown
J Palma, B Tokarz-Deptuła, J Deptuła… - … European Journal of …, 2018 - termedia.pl
In contrast to adaptive antibodies, natural antibodies are present in a non-immunised
organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural …
organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural …
Age-related autoimmunity
Z Vadasz, T Haj, A Kessel, E Toubi - BMC medicine, 2013 - Springer
Older persons have higher autoimmunity but a lower prevalence of autoimmune diseases. A
possible explanation for this is the expansion of many protective regulatory mechanisms …
possible explanation for this is the expansion of many protective regulatory mechanisms …