Systemic lupus erythematosus (SLE) is characterized by high-titer serological
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …

The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment
and care, but cardiovascular disease (CVD) still remains an important clinical problem, since …

Insights into the important contribution of inflammation and immune functions in the
development and progression of atherosclerosis have greatly improved our understanding …

Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-
tuning of the recognition and response to foreign threats. However, in health there are some …

Systemic Lupus Erythematosus (SLE) is characterized by a wide spectrum of auto-
antibodies which recognize several cellular components. The production of these self …

The incidence of autoimmune diseases is increasing. Antinuclear antibody (ANA) testing is a
critical tool for their diagnosis. However, ANA prevalence in healthy persons has increased …

Studying the phenomenon of cellular senescence has been hindered by the lack of
senescence-specific markers. As such, detection of proteins informally associated with …

A healthy immune system results from a balance of stimulatory and inhibitory pathways that
allow effective responses to acute insults, without descending into chronic inflammation …

In contrast to adaptive antibodies, natural antibodies are present in a non-immunised
organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural …

Older persons have higher autoimmunity but a lower prevalence of autoimmune diseases. A
possible explanation for this is the expansion of many protective regulatory mechanisms …