Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Ferroptosis is a recently discovered essential type of cell death that is mainly characterized
by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a …

Regulated cell death (RCD) has a significant impact on development, tissue homeostasis,
and the occurrence of various diseases. Among different forms of RCD, ferroptosis is …

Significance: Autophagy is a self-degrading process that determines cell fate in response to
various environmental stresses. In contrast to autophagy-mediated cell survival, the signals …

Despite significant advances in cancer therapy over the years, its complex pathological
process still represents a major health challenge when seeking effective treatment and …

Malignant ascites in advanced hepatocellular carcinoma (HCC) is a complex clinical
problem that lacks effective treatments. Due to the insensitivity of advanced HCC cells to …

Resveratrol is an organic compound widely studied for its therapeutic uses. We investigated
whether resveratrol exerts cardioprotective effects by inhibiting ferroptosis via the Sirt1/p53 …

As a type of immunogenic cell death, ferroptosis participates in the creation of immunoactive
tumor microenvironments. However, knowledge of spatial location of tumor cells with …

Ferroptosis is characterized by iron accumulation and lipid peroxidation. However, a clinical
dose of Fe3O4 nanoparticles could not cause effective ferroptosis in tumors, and the …

Iron is essential for all organisms and cells. Diseases of iron imbalance affect billions of
patients, including those with iron overload and other forms of iron toxicity. Excess iron load …