Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate
immune response and its activation by bacterial endotoxin is responsible for chronic and …

Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies
available other than ICU treatment. The patient outcome is determined by a complex …

Inflammation is a complex physiological process triggered in response to harmful stimuli. It
involves cells of the immune system capable of clearing sources of injury and damaged …

Sepsis often leads to multiple organ failure or even death and is a significant health problem
that contributes to a heavy economic burden. The lung is the first organ to be affected by …

Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …

Microglia, the resident macrophages of the brain parenchyma, are key players in central
nervous system (CNS) development, homeostasis, and disorders. Distinct brain pathologies …

Thrombosis is a common consequence of infection that is associated with poor patient
outcome. Nevertheless, the mechanisms by which infection-associated thrombosis is …

The critical role of inflammatory processes in health and disease has long been recognized,
1 yet the detailed molecular mechanisms and biological events that regulate the progression …

Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of
critical illness. Several weakness syndromes are summarized under the term intensive care …

Background To mimic systemic inflammation in humans, different animal models have been
developed. Since these models are still discussed controversially, we aimed to …