Long COVID, a comprehensive systematic scoping review

H Akbarialiabad, MH Taghrir, A Abdollahi… - Infection, 2021 - Springer
Purpose To find out what is known from literature about Long COVID until January 30, 2021.
Methods We undertook a four-step search with no language restriction. A preliminary search …

[HTML][HTML] Understanding kratom use: a guide for healthcare providers

MT Swogger, KE Smith, A Garcia-Romeu… - Frontiers in …, 2022 - frontiersin.org
Kratom (Mitragyna speciosa Korth., Rubiaceae) is a plant native to Southeast Asia, where it
has been used for centuries as a mild stimulant and as medicine for various ailments. More …

Kratom—pharmacology, clinical implications, and outlook: a comprehensive review

SC Eastlack, EM Cornett, AD Kaye - Pain and therapy, 2020 - Springer
Kratom, or Mitragyna, is a tropical plant indigenous to Southeast Asia, with unique
pharmacological properties. It is commonly consumed by preparing the leaves into …

Current perspectives on the impact of Kratom use

C Veltri, O Grundmann - Substance abuse and rehabilitation, 2019 - Taylor & Francis
The leaves from the tree Mitragyna speciosa, commonly known as Kratom, in the coffee
plant family (Rubiaceae) are commonly used in their native habitat of Southeast Asia as a …

Kratom (Mitragyna speciosa): User demographics, use patterns, and implications for the opioid epidemic

A Garcia-Romeu, DJ Cox, KE Smith, KE Dunn… - Drug and alcohol …, 2020 - Elsevier
Abstract Background Kratom, a Southeast Asian plant with opioid-receptor mediated effects,
has emerged as a potential substance of abuse, with limited data on its use and effects. This …

7-Hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects

AC Kruegel, R Uprety, SG Grinnell… - ACS central …, 2019 - ACS Publications
Mitragyna speciosa, more commonly known as kratom, is a plant native to Southeast Asia,
the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for …

Kratom as a substitute for opioids: results from an online survey

MA Coe, JL Pillitteri, MA Sembower, KK Gerlach… - Drug and alcohol …, 2019 - Elsevier
Abstract Background Kratom is a South Eastern Asian tree whose leaves are used to make
tea-like brews or swallowed in powdered form for various health and well-being reasons …

Investigation of the adrenergic and opioid binding affinities, metabolic stability, plasma protein binding properties, and functional effects of selected indole-based …

S Obeng, SH Kamble, ME Reeves… - Journal of medicinal …, 2019 - ACS Publications
Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic
receptor binding and functional effects, in vivo antinociceptive effects, plasma protein …

Activity of Mitragyna speciosa (“Kratom”) Alkaloids at Serotonin Receptors

F León, S Obeng, M Mottinelli, Y Chen… - Journal of medicinal …, 2021 - ACS Publications
Kratom alkaloids have mostly been evaluated for their opioid activity but less at other targets
that could contribute to their physiological effects. Here, we investigated the in vitro and in …

The abuse potential of kratom according the 8 factors of the controlled substances act: implications for regulation and research

JE Henningfield, RV Fant, DW Wang - Psychopharmacology, 2018 - Springer
Rationale Consideration by the US Drug Enforcement Administration and Food and Drug
Administration of placing kratom into Schedule I of the Controlled Substances Act (CSA) …