Epstein-Barr Virus (EBV) is an extremely successful human herpes virus, which infects
essentially all human beings at some time during their life span. EBV infection and the …

Objective This collaboration between the American College of Rheumatology and the
American Association of Hip and Knee Surgeons developed an evidence‐based guideline …

Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several
cancers. While these immunotherapies have improved patient outcomes in many clinical …

Background Biologics are used for the treatment of rheumatoid arthritis and many other
conditions. While the efficacy of biologics has been established, there is uncertainty …

Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical,
emotional and socioeconomic consequences. Despite advances in targeted biologic and …

Pain is ultimately a perceptual phenomenon. It is built from information gathered by
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …

Background Tumour necrosis factor α (TNFα) inhibitors are frequently used to treat
rheumatoid arthritis, but whether use of a different TNFα inhibitor can improve patient …

Objectives This project was undertaken to assess the risk of malignancy in patients with
rheumatoid arthritis treated with tumour necrosis factor inhibitors (TNFi) in clinical practice …

Background: Certolizumab pegol is a PEGylated tumour necrosis factor inhibitor. Objective:
To evaluate the efficacy and safety of certolizumab pegol versus placebo, plus methotrexate …

Objectives To review the evidence for the efficacy and safety of biological agents in patients
with rheumatoid arthritis (RA) to provide data to develop treatment recommendations by the …